α-硫辛酸联合甲钴胺治疗腕管综合征疗效电生理学观察  

Treatment of carpal tunnel syndrome with alpha-lipoic acid

作　　者：孙太欣[1] 孙晨曦[1] 任志宏[1] 周国平[1] 

机构地区：[1]首都医科大学电力教学医院神经内科,北京100073

出　　处：《癫痫与神经电生理学杂志》2012年第6期337-340,共4页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：探讨a-硫辛酸在腕管综合征（CTS）治疗中的作用。方法：72例CTS患者随机分为两组：对照组：给予甲钴胺＋维生素B1治疗；硫辛酸组：在给予甲钴胺＋维生素B1的同时联合应用a-硫辛酸治疗。于治疗前后行神经电生理检查，评价治疗效果。结果：硫辛酸组总有效率为91％，优于对照组（有效率为70％）。两组经治疗后感觉神经传导速度、感觉神经动作电位波幅均有提高，但硫辛酸组感觉神经传导速度提高更明显。两组对复合肌动作电位波幅改变均不明显。结论：CTS早期应用甲钴胺联合a-硫辛酸能起到更好的治疗效果。Objective： Todiscuss the treatment of a-lipoic acid in carpal tunnel syndrome（CTS） Methods： 72 patients were randomly divided into two groups. The control group were injected then taken orally mecobalamin ＋ vitamin Bl. The treatment group were given intravenous a-lipoic acid and injected mecobalamin ＋ vitamin B1, then oral meeobalamin ＋ vitamin B1. All patients received electrophysiologi- cal examination before and after the treatment. Results： The total effective rate of the treatment group was 91.43%, better than the control group. After the treatment, the sensory nerve conduction velocity and the sensory nerve action potential amplitudes increased in two groups. But in the treatment group, the sensory nerve conduction velocity was improved more significantly than in the control. The compound muscle action potential amplitude changes were not obvious in two groups. Conclusion： Combined use of mecobalamin and a-lipoic aci in CTS earlier can play a better role of treatment effect.

关 键 词：腕管综合征(CTS) 甲钴胺 A-硫辛酸 

分 类 号：R971[医药卫生—药品] R746[医药卫生—药学]