慢性丙型肝炎合并甲状腺功能异常回顾性分析  

Review analysis of chronic hepatitis C patients with thyroid dysfunction

作　　者：许英霞[1] 陈新月[1] 黄雁翔[2] 马丽娜[1] 郑燕红[1] 王群[1] 

机构地区：[1]首都医科大学附属北京佑安医院国际医疗部,100069 [2]首都医科大学附属北京佑安医院北京市肝病研究所,100069

出　　处：《北京医学》2012年第12期1034-1036,共3页Beijing Medical Journal

基　　金：国家"十一五"科技重大专项(2008ZX10002-013)

摘　　要：目的探讨慢性丙型肝炎(chronic hepatitis C,CHC)患者合并甲状腺功能异常的发生情况及干扰素(IFN)对甲状腺功能的影响。方法以2008年3月至2012年2月首都医科大学附属北京佑安医院的抗-HCV筛查人群为研究对象,分析抗-HCV阳性率、HCV RNA阳性率、IFN治疗率及CHC患者甲状腺功能异常发生情况。结果共筛查出HCV RNA阳性者4470例,其中1697例(38.0%)接受IFN治疗。CHC患者监测甲状腺功能者1485例,甲状腺功能异常率为15.4%。IFN治疗组与非IFN治疗组甲状腺功能异常率分别为18.5%和13.2%,差异有统计学意义(P﹤0.05)。将2008年3月至2010年2月和2010年3月至2012年2月的资料比较,CHC患者IFN治疗率、甲状腺功能监测率、IFN治疗组甲状腺功能监测率的差异均有统计学意义[35.1%vs.40.3%,30.2%vs.35.7%,55.6%vs.60.6%;P均﹤0.05]。结论 4年间CHC确诊例数呈上升趋势,IFN治疗率显著增高,甲状腺功能异常与IFN治疗有关,对CHC患者尤其是IFN抗病毒治疗的患者应定期监测甲状腺功能。Objective To explore the status of thyroid dysfunction in chronic hepatitis C （CHC） patients and the relation between thyroid dysfunction and interferon （IFN） therapy. Methods A retrospective study was carried out in pa- tients who were screened anti-HCV during March, 2008 to February, 2012 in Beijing You＇an hospital. The rates of an- ti-HCV seropositive, HCV RNA seropositive, IFN treatment and the incidence of thyroid dysfunction were analyzed. Resuits A total of 4 470 HCV RNA seropositive patients were enrolled in the study, 1 697 （38.0%） patients received IFN treatment, 1 485 patients of CHC received thyroid function monitoring, 15.4% abnormal. Patients with thyroid dysfunction in IFN group and non-IFN group respectively accounted for 18.5% and 13.2% （P 〈 0.05）. Compared March, 2008 to February, 2010 with March, 2010 to February, 2012, the rate of IFN therapy and thyroid function monitoring in CHC, and the rate of thyroid function monitoring in IFN group were respectively 35.1% vs. 40.3%, 30.2% vs. 35.7%, 55.6% vs. 60.6% （all P 〈 0.05）. Conclusion The number of patients who diagnosed CHC has shown ascendant trend, and the rate of IFN therapy also has increased significantly in the past 4 years. Thyroid dysfunction is related to IFN therapy. To CHC patients, especially those with IFN therapy, thyroid function should be monitored regularly.

关 键 词：慢性丙型肝炎 干扰素 甲状腺功能异常 

分 类 号：R512.63[医药卫生—内科学]