低温药物灌肠对大鼠急性放射性直肠损伤的防治效果研究  

Study for the effect of rats acute radiation rectal injury prevention by low temperature drug enema

作　　者：邱云芳[1] 叶赟[2] 张曦霞[1] 张兰凤[1] 朱顺新[2] 邓锦玲[1] 张建兵[1] 刘继斌[1] 蔡晶[1] 

机构地区：[1]江苏省南通市肿瘤医院,江苏南通226000 [2]南通大学,江苏南通226000

出　　处：《护士进修杂志》2012年第24期2217-2219,共3页Journal of Nurses Training

基　　金：江苏省南通市科技局2009年基金项目(编号:S2009052)

摘　　要：目的探讨低温加复方云南白药灌肠对大鼠急性放射性直肠炎的防治效果。方法根据作者对前期大鼠急性放射性直肠炎保留灌肠模型筛选结果,制作大鼠急性放射性直肠炎模型30只,随机分对照组、低温加复方云南白药灌肠组(低温药物组)、复方云南白药灌肠组(药物组)各10只,并选未造模大鼠10只作为对照组。其中低温药物组在X线照射前将含有N0制冷剂的深静脉导管插入肛门约4cm后再给予照射,照射后低温药物组与药物组均采用复方云南白药灌肠2ml/次,1次/d;对照组用等量生理盐水灌肠。观察各组一般征象并评分,并于灌肠后第8d、14d分别解剖部分大鼠,观察直肠组织病理学及血清IL-6、IL-8。结果灌肠后一般征象评分,1～7d低温药物组、药物组均较对照组有统计学差异,8～14d低温药物组较药物组评分差异有显著意义(P<0.05)。血清IL-6、IL-8低温药物组较对照组和药物组差异均有显著意义(P<0.05),且直肠组织病理较对照组、药物组明显改善。结论低温加药物灌肠能够有效防治急性放射性直肠损伤的反应。Objective To study the effect of yunnan baiyao powder combined with low temperature retention enema on acute radiation rectal injury of rats. Method Based on the previous research, 30 rats model of acute radiation rectal injury were established and randomly divided into three groups, Observation group, Yunnan baiyao powder combined with low temperature group （referred as cold medicine group） and Yunnan baiyao powder group （referred as medicine group）, 10 rats in each group, and 10 normal rats were set as control group. Before the X-rays irradiation use a deep venous catheter containing the refrigerant no inserted into the anus, and then exposure about 4 cm in the cold medicine group, both the cold medicine group and the medicine group use Yunnan baiyao powder enema 2 mL per time 1/d. Observation group and control group were treated by 0. 9% sodium chloride injection. General signs rectal histopathology and serum I L-6, I L-8 were observed in each group after 8 d,14 days of enema. Result The general signs of cold medicine group and medicine group were significantly different （P〈0.05） compared with observation group at 1 to 7 days. Cold medicine group were significantly different（P〈0.05） compared with observation group at 8-14 d. Serum I L-6,8 were significant different（P〈0.05） compared with observation group and medicine group, and the rectal pathology were also significantly improved than the two groups. Conclusion Yunnan baiyao powder combined with bow temperature retention enema was effective to treat rat radiation rectal injury. It can significantly improve the effect of the rectal mucosal edema and ulceration.

关 键 词：放射疗法 辐射损伤 大鼠 预防用药 护理 

分 类 号：R473.73[医药卫生—护理学]