基于近红外光谱的小鼠肝移植瘤激光热疗实时监测研究  

Real-time monitoring research on laser thermotherapy for implanted rat liver cancers based on near infrared spectroscopy

作　　者：张华[1,2] 花国然[2] 钱爱平[1] 钱志余[3] 

机构地区：[1]南通大学杏林学院,江苏南通226019 [2]南通大学机械工程学院,江苏南通226019 [3]南京航空航天大学生物医学工程系,江苏南京210016

出　　处：《激光杂志》2012年第6期67-68,70,共3页Laser Journal

基　　金：江苏省自然科学基金(BK2008184);南通大学杏林学院科研基金项目(2010K128)

摘　　要：以近红外光谱技术为监测手段,研究小鼠皮下肝移植瘤激光热疗过程中病变组织光学参数变化规律。建立病变组织温度和光学参数的数学模型以指导激光热疗,并通过术后病理切片验证热疗效果。试验结果表明,利用近红外光谱技术监测病变组织的光学参数变化可对激光热疗实现实时监测。The variation of optical parameters in subcutaneous implanted rat liver cancers during laser induced themlotherapy （HIT） have been investigated with the method of near infrared spectroscopy technology （ NIST）. A mathematical model of tenrperature and optical parameters for diseased tissue has been established to guide LITT. The therapeutic effects are confirmed with postoperative pathologic. The experimental results show that NIRST is useful to achieve real - time monitoring iu LITT with monitoring the changes of the reduced scattering coefficients.

关 键 词：激光热疗 近红外光谱 光学参数 数学模型 

分 类 号：Q631[生物学—生物物理学]