表皮生长因子(EGF61A/G)基因多态性与精神分裂症易感性关系的Meta分析  

Correlation between epidermal growth factor (EGF61A/G) gene polymorphism andschizophrenia susceptibility:A Meta analysis

作　　者：何大莉[1] 曾照芳[1] 

机构地区：[1]重庆医科大学检验医学院,临床检验诊断学教育部重点实验室,重庆市重点实验室,重庆400016

出　　处：《激光杂志》2012年第6期75-76,共2页Laser Journal

摘　　要：目的:评价表皮生长因子(EGF61A/G)基因多态性与精神分裂症易感性的相关性。方法:全面检索PubMed、Web of Science、GoogleScholar database、维普、万方数据库,收集EGF61A/G基因多态性与精神分裂症相关性的文献。用Meta分析评价EGF61A/G各基因型(A vs.G、AA vs.GG、AA vs.GA+GG、AA+GA vs.GG)分布在精神分裂病组与对照组中是否有差异。结果:共纳入6篇文献,共有精神分裂症患者1038例,健康对照1190例。Meta分析未发现EGF61A/G基因多态性与精神分裂症具有相关性(A vs.G:OR=0.99,95%CI=0.87 1.12;AA vs.GG:OR=1.00,95%CI=0.77-1.29;AA vs.GA+GG:OR=0.89,95%CI=0.71-1.11;AA+AG vs.GG:OR=1.07,95%CI=0.0.89-1.28)。结论:本研究未鉴定出EGF61A/G基因多态性与和精神分裂症的相关性。Objective： To evaluate the correlation between epidermal growth factor（EGF61A/G） gene polymoqohism and schizophrenia susceptibility. Methods： We searched PubMed, Web of Science, Google Scholar database, Weipu, Wanfang database and collected all the publications about the correlation between EGF61A/G polymorphism and schizophrenia susceptibility. Meta analysis was performed for assessing the difference of EGF61A/G genotype distribution （A vs. G,AA vs. GG, AA vs. GA ＋ GG, AA ＋ GA vs. GG）between two groups （schizophrenia group and control group）o Results：A total of 6 studies involving 1038 schizophrenia patients and 1190 healthy controls were included. The meta analysis showed that, there was no significant correlation between EGF61A/G gene polymorphism and schizophrenia susceptibility（A vs.G：OR= 0.99,95% CI = 0.87 - 1.12;AA vs. GG：OR = 1.00,95% CI = 0.77 - 1.29;AA vs. GA ＋ GG： OR =0.89, 95% CI = 0.71 1.11;AA＋AG vs. GG：OR = 1.07, 95% CI = 0.89-1.28}. conclusion：This meta analysis didn＇t demonstrate the correlation between EGF61A/G gene polymorphism and schizophrenia susceptibility.

关 键 词：表皮生长因子 基因多态性 精神分裂症 META分析 

分 类 号：R477[医药卫生—护理学]