水相研磨技术合成2-取代-2,3-二氢-4(1H)-喹唑啉酮(英文)  

Synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinones by an aqueous grinding technique

作　　者：王敏[1] 向刚伟 高晶晶[1] 

机构地区：[1]渤海大学化学化工与食品安全学院,辽宁锦州121000 [2]中国石油四川石化责任有限公司生产一部,四川成都611930

出　　处：《化学研究与应用》2012年第12期1800-1804,共5页Chemical Research and Application

基　　金：辽宁省科技厅研究基金项目(20091001)资助;辽宁省教育厅研究基金项目(L2011198)资助

摘　　要：以2-氨基苯甲酰胺和醛或酮为原料,苯磺酸亚铁为催化剂,采用研磨技术在水相进行反应,高效合成了2,3-二氢-4(1H)-喹唑啉酮。产品结构通过IR,1H NMR,质谱和元素分析进行表征。提出了可能的催化作用机理。该方法具有产率高、操作和后处理过程简便、催化剂能循环使用等优点。An efficient and eeo-friendly synthesis of 2-substituted-2,3-dihydm-4 （1H）-quinazolinones had been accomplished by a reaction of 2-anthranilamide with aldehydes or ketones in the presence of ferrous benzenesulfonate using an aqueous grinding tech- nique. The structures of products were characterized by IR,1H NMB, mass spectra and elemental analysis. A probable catalytic mechanism for this reaction was proposed. Excellent yields of the products, simple operation and work-up, and reeyclable catalyst were attractive features of this green protocol.

关 键 词：研磨技术 2  3-二氢-4(1H)-喹唑啉酮 2-氨基苯甲酰胺 醛 酮 金属苯磺酸盐 

分 类 号：O626.4[理学—有机化学]