无水硫酸铁催化多组分反应合成酰胺基烷基萘酚(英文)  

Efficient synthesis of amidoalkyl naphthols by a Fe_2(SO_4)_3-catalyzed multicomponents reaction

作　　者：宋志国[1] 刘连利[1] 孙啸虎[1] 王洋[1] 崔岩[1] 

机构地区：[1]渤海大学实验管理中心,辽宁省硅材料工程技术研究中心,辽宁锦州121000

出　　处：《化学研究与应用》2012年第12期1805-1809,共5页Chemical Research and Application

基　　金：辽宁省硅材料工程中心项目(2009402007)资助

摘　　要：无溶剂、80℃条件下,无水硫酸铁可有效催化2-萘酚、醛、和胺/尿素三组分"一锅法"合成酰胺基烷基萘酚。考察了溶剂条件和催化剂用量对产率的影响。与已报道方法相比,该方法具有反应条件温和、反应时间短、产率高、不使用有机溶剂、催化剂廉价易得和后处理步骤简便等优点。A new protocol for the synthesis of amidoalkyl naphthols by a one-pot three-component condensation of 2-naphthol, aldehydes,amides/urea under solvent-free conditions at 80℃ using catalytic amount of anhydrous ferric sulfate, had been developed. The effects of different solvents conditions and the amount of catalyst on the yields were investigated. Compared to the reported methods, the advantages of this novel protocol lie in mild reaction conditions, short reaction time, the high yields, avoidance of organ- ic solvent, use of inexpensive catalyst and simple work-up procedure.

关 键 词：酰胺基烷基萘酚 多组分反应 无水硫酸铁 一锅法合成 无溶剂条件 

分 类 号：O625.6[理学—有机化学]