卓酚酮基础的查尔酮衍生物(E)-5-溴-3-(3-芳基丙烯酰基)卓酚酮的合成(英文)  

Synthesis of tropolone-based chalcone derivatives(E)-5-bromo-3-(3-arylacryloyl)tropolones

作　　者：张红[1] 李阳[1] 

机构地区：[1]渤海大学超精细化学品研究所,辽宁锦州121000

出　　处：《化学研究与应用》2012年第12期1848-1852,共5页Chemical Research and Application

摘　　要：3-乙酰基-5-溴-卓酚酮与不同取代的苯甲醛类化合物通过Claisen-Schmidt缩合反应合成一系列结构新颖的卓酚酮取代的查尔酮类衍生物。该方法使用5%KOH溶液作为催化剂,50%甲醇水溶液作为溶剂,具有操作简便、反应条件温和、收率高等优点。所合成标题化合物的结构经IR、1H NMR、MS和元素分析得以证实。A facile and general synthesis of a series of new tropolone-based chalcone compounds by Claisen-Schmidt condensation reaction from 3-acetyl-5-bromotropolone and substituted benzaldehydes was described. The method using 5% aq. KOH as catalyst and 50% aq. methanol as solvent was attractive since it specifically generates（E）-isomers with high yields under mild reaction conditions. The structures of the title compounds were characterized by IR,IH NMR,and MS techniques.

关 键 词：卓酚酮基查尔酮 Claisen—Schmidt缩合 3-乙酰基-5-溴-卓酚酮 苯甲醛 

分 类 号：O625[理学—有机化学]