阿戈美拉汀多晶型研究  

Study on the polymorphs of agomelatine

作　　者：朱建强[1] 魏文涛[1] 代奕[1] 赵健[1] 张殿镇[1] 

机构地区：[1]天津泰普药品科技发展有限公司,天津300193

出　　处：《中国药物化学杂志》2012年第6期495-498,共4页Chinese Journal of Medicinal Chemistry

摘　　要：目的研究抗抑郁药阿戈美拉汀的多晶型现象。方法比较阿戈美拉汀不同晶型的制备方法,采用红外光谱和粉末X-射线衍射法测定不同晶型的特征。结果发现了阿戈美拉汀的一种新晶型(Ⅹ型),并通过红外光谱和粉末Ⅹ-射线衍射法确定其不同于文献报道的Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ、Ⅵ等6种晶型。结论初步稳定性研究结果表明,阿戈美拉汀Ⅹ晶型具有适合作为药物应用的潜力。Agomelatine offers superior antidepressant efficacy in all depressed patients, whatever the severity of depression. The aim of this article is to study the polymorphs of agomelatine through investigating the preparation methods of several crystal forms of agomelatine. The polymorphs of agomelatine are determined by IR spectra（IR） ,powder X-ray diffraction. A new crystal form（ X ） is found and determined. It differs from the six crystal forms reported in the literature. The preliminary stability study shows that the crystal form（ X ） can be applied in pharmaceutics.

关 键 词：阿戈美拉汀 多晶型 抗抑郁药 

分 类 号：R971[医药卫生—药品]