β受体阻滞剂对心肌梗死大鼠心肺复苏后自主循环恢复率及实验室指标的影响  

Effect of β-Receptor Blocker on Return of Spontaneous Circulation and Laboratory Index During Cardiopulmonary Resuscitation in Myocardial Infarction Rats

作　　者：赵晓静[1] 彭卓[1] 陈尔秀[1] 刘健[2] 高艳霞[1] 任云霞[1] 李丽君[1] 

机构地区：[1]西安交通大学医学院第二附属医院急诊科,陕西省710004 [2]西安交通大学医学院机能教学与实验中心

出　　处：《中国循环杂志》2012年第6期462-465,共4页Chinese Circulation Journal

基　　金：陕西省科技攻关(编号:2009K16-02)

摘　　要：目的:观察长期应用β受体阻滞剂对心肌梗死(心梗)大鼠心肺复苏后自主循环恢复率及实验室指标的影响。方法:雄性SD大鼠随机分为心梗无药组,心梗喂药组,另设假手术组,每组15只大鼠。采用气管插管,结扎冠状动脉(冠脉)前降支制作急性心梗模型。窒息法制作大鼠心肺复苏模型。结果:①自主循环恢复率:心梗无药组与假手术组比较下降;心梗喂药组与心梗无药组比较增高;②大鼠夹闭气管前心率:心梗无药组与假手术组比较夹闭气管前心率增高,心梗喂药组与心梗无药组比较夹闭气管前心率明显降低。上述比较差异均有统计学意义(P<0.05～0.01);③肾上腺素用量:假手术组、心梗无药组、心梗喂药组三组间比较差异无统计学意义(P>0.05);④自主循环恢复时间:自开始复苏至复苏成功时间三组间比较差异无统计学意义(P>0.05);⑤实验室指标:三组实验大鼠复苏成功者较未成功者的动脉氧分压均升高,其中假手术组和心梗无药组成功者血钾离子浓度降低,差异均有统计学意义(P<0.05);三组实验大鼠复苏成功者血钾离子浓度(5.9±0.7)mmol/L。结论:β受体阻滞剂长期应用提高心梗大鼠心肺复苏成功率。心肺复苏中血钾离子浓度持续增高影响心肺复苏成功率。Objective ： To observe the effect of long term using of β-receptor blocker on return of spontaneous circulation （ROSC） and laboratory index during cardiopulmonary resuscitation （CPR） in myocardial infarction （MI） rats. Methods： Male SD rats were randomly divided into 3 groups：Pseudo-operation （Pseudo） group, MI without medication （No medication） group and MI with metoprolol （Medication） group, n= 15 in each group. Acute MI model was established by ligation of anterior descending coronary artery and CPR model was established by asphyxia of clamping tracheal tube in experimental rats. Results ： （ 1 ） The rate of ROSC was lower in No medication group than that in Pseudo group, it was higher in Medication group than that in No medication group. （2） The heart rate before clamping tracheal tube increased in No medication group than that in Pseudo group,and it decreased in Medication group than that in No medication group; all P〈0. 05 -0. 01. （3） The total epinephrine dose used in 3 groups were similar, P〉 0. 05. （4） The recovery time of ROSC had no real differences among 3 groups ,P〉0. 05. （5） The laboratory index presented that CRP success rats had increased arterial 02 pressure and decreased concentration of blood K＋ ,P〈0. 05, and the average concentration of blood K＋ in CRP success rats was （5.9±0. 7） mmol/L in all 3 groups. Conclusion ： Long term using of G-receptor blocker may elevate the success rate of CPR in MI rats, and the increased concentration of blood K＋ may affect the success rate of CPR.

关 键 词：心肺复苏术 Β受体阻滞剂 自主循环恢复率 肾上腺素 

分 类 号：R541[医药卫生—心血管疾病]