自乳化辅料对川芎嗪缓释固体分散体释放度的影响  

Effect of adding self-emulsifying excipients on release rate of tetramethylpyrazine-release solid dispersion

作　　者：王利胜[1] 陈晓丹[1] 吕耿彬[1] 涂星[1] 吴俊洪[1] 

机构地区：[1]广州中医药大学中药学院,广州510006

出　　处：《中国新药杂志》2012年第23期2800-2803,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30873443);广东省科技计划项目(2010B030700039)

摘　　要：目的:考察自乳化辅料的加入对川芎嗪缓释固体分散体释放度的影响,为剂型的改进提供一定的依据。方法:HPLC法测定川芎嗪缓释固体分散体(tetramethylpyrazine solid dispersion,TMP-SD)与川芎嗪自乳化缓释固体分散体(tetramethylpyrazine self-emulsifying solid dispersion,TMP-SESD)的累积释放度,比较二者的释药特征。结果:TMP-SD 12 h释放量仅为(39.26±1.86)%,而TMP-SESD释放量可达(98.33±2.02)%。结论:自乳化辅料的加入解决了TMP-SD释放度过低的问题,达到理想的释药效果。Objective： To determine the effect of adding self-emulsifying excipients on release rate of tet- ramethylpyrazine-release solid dispersion （TMP-SD）. Methods： The in vitro dissolution between TMP-SD and tetramethylpyrazine-release self-emulsifying solid dispersion （TMP-SESD） was compared. Results： The cumula- tive release rate of TMP-SD was （39.26±1. 86）% within 12 h, whereas that of TMP-SESD was （98.33±2.02） %. Conclusion ： Addition of self-emulsifying excipients to the TMP-SD can greatly increase the drug re- lease rate.

关 键 词：自乳化 川芎嗪 缓释 固体分散体 释放度 

分 类 号：R286.2[医药卫生—中药学] R94[医药卫生—中医学]