托特罗定PLGA微球的制备及其体外释药的研究  

Preparation of tolterodine PLGA micorspheres and its in vitro release properties

作　　者：刘文华[1] 潘振祥[1] 李又欣[2] 孙凤英[2] 

机构地区：[1]吉林大学第二医院麻醉科,长春130041 [2]吉林大学生命科学学院,长春130012

出　　处：《中国新药杂志》2012年第23期2821-2825,共5页Chinese Journal of New Drugs

摘　　要：目的:考察制备工艺对托特罗定微球的体外性质的影响。方法:采用O/W溶剂挥发法制备托特罗定聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]微球,采用扫描电镜,差示扫描量热分析,红外光谱对微球进行定性分析,并对微球的粒径、包封率和体外释放率等性质进行了考察。结果:托特罗定微球光滑圆整,粒径均一。PLGA相对分子质量对微球的包封率和体外释放度影响较大。脂肪酸能显著改善微球的包封率,但是对体外释放的影响有限。结论:制备工艺参数的变化对托特罗定PLGA微球体外性质影响显著。Objective：To investigate the impact of preparation technique on in vitro release properties of tolterodine-loaded microspheres. Methods： Tolterodine poly （lactic-co-glycolic acid） （PLGA） microspheres were prepared with O/W emulsion solvent evaporation method and characterized by SEM,DSC and FT-IR. The particle size,encapsulation efficiency,and in vitro release rate of tolterodine from the microspheres were studied. Results： The microspheres were spherical in shape with a smooth surface. The effects of the molecular weight of PLGA on the encapsulation efficiency and in vitro release rate were significant. The fattic acids significantly improved the drug encapsulation,but showed limited effects on the in vitro release of toherodine from microspheres. Conclusion： The impact of formulation factors on in vitro release properties of tolterodine-loaded microspheres is evident.

关 键 词：托特罗定 微球 PLGA 体外释药 

分 类 号：R943.41[医药卫生—药剂学]