醋炙对芫花毒性和药效影响的实验研究  

Experimental Study on Toxicity and Efficacy of Genkwa Flos stir-baked with Vinegar

作　　者：代光秀 

机构地区：[1]临沂市中医院,山东临沂276000

出　　处：《中华中医药学刊》2012年第12期2766-2767,共2页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:考察醋炙芫花对毒性和药效的影响。方法:急性毒性试验采用BLiss法计算芫花和醋芫花的半数致死量;采用利尿试验试验,观察芫花和醋芫花不同极性溶剂提取物和不同极性部位对小鼠利尿作用的影响。结果:醋炙后芫花毒性明显毒性降低,乙酸乙酯部位是芫花的毒性部位。与对照组相比,芫花、醋芫花醇提物、石油醚部位、乙酸乙酯部位可明显促进利尿作用。与生品比较,醋炙后各组利尿作用皆明显增强。结论:芫花醋炙后毒性显著降低,药效增强。芫花的乙酸乙酯部位既是其毒性部位,又是其药效学主要部位。Objective ： To study toxicity and efficacy of Genkwa Flos by processing with Vinegar. Methods ： Acute tox icity of LI）50 was calculated using Bliss, using diuretic effects to research the effect of the ethanol extracts of from differ ent polar parts of Genkwa Flos and Vinegar - preparing Genkwa Flos. Results ：The toxicity of Genkwa Flos processed with vinegar was significantly reduced, the part of ethly acelate was part of toxicity. As compared with the control group, the di uretic effects of alcohol extract and the parts of petroleum ether and ethly acelate of Genkwa Flos and vinegar preparing Genkwa Flos had significant differences. The diuretic effects of Vinegar - preparing Genkwa Flos were enhanced com pared with Genkwa Flos. Conclusion ： Vinegar - preparing Genkwa Flos can significantly reduce toxicity and enhance effi cacy. The parts of ethyl acelate are both parts of harmacodynamics and toxicity.

关 键 词：芫花 醋芫花 急性毒性 利尿作用 

分 类 号：R285.5[医药卫生—中药学]