S-布洛芬分子印迹膜的制备与手性拆分性能  

Preparation and Chiral Resolution Performance of S-Ibuprofen Molecularly Imprinted Membranes

作　　者：刘丽娟[1] 许振良[1] 张颖[1] 

机构地区：[1]华东理工大学化学工程联合国家重点实验室.化学工程研究所膜科学与工程研发中心,上海200237

出　　处：《高分子材料科学与工程》2012年第12期159-163,共5页Polymer Materials Science & Engineering

基　　金：广东省科委重大科技专项(2011A080403004);化学工程联合国家重点实验室课题

摘　　要：采用聚偏氟乙烯(PVDF)中空纤维膜为支撑体,制备了S-布洛芬分子印迹膜,并对膜的选择结合性及手性拆分性能进行了研究。研究结果表明,S-布洛芬分子印迹复合膜对S-布洛芬具有较好的选择结合性,在膜上的结合量达到22.8μmol/g。膜的错流过滤实验表明,S-布洛芬透过膜的速率大于R-布洛芬,分离因子为1.17,这将有利于外消旋布洛芬的分离。扫描电镜(SME)也同样表明,在膜的表面涂上了一薄层印记膜。S-ibuprofen molecularly imprinted membrane was prepared using PVDF hollow fiber membrane as the support. The selective binding properties and chiral resolution performance of the membranes were investigated. The results show that the S-ibuprofen molecularly imprinted membrane has the high binding capacity for S-ibuprofen, the binding amount for S-ibuprofen is up to 22.8 μmol/g. Permeation experiments of S-ibuprofen and R-ibuprofen across the membrane imprinted with S-ibuprofen show that the membrane is enantioselective, diffusion of the template enantiomer faster than that of its optical antipode. The separation factor is up to 1.17. The permeation mechanism coincides with ＂facilitated transport＂ or ＂facilitated diffusion＂ model. The SEM results also indicate that a thin imprinted membrane is coated on the surface of the PVDF hollow fiber membrane.

关 键 词：布洛芬 分子印迹膜 手性拆分 

分 类 号：TQ028.8[化学工程]