止痛贴膏处方中渗透促进剂的筛选  

Screening of penetration enhancers in prescription of Zhitong Emplastrum

作　　者：张永强[1] 王琼[1] 兰颐[1] 安静[1] 吴清[1] 杜守颖[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《北京中医药大学学报》2012年第11期769-772,790,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重大新药创制项目(No.2009ZX09502-008)

摘　　要：目的筛选止痛贴膏中渗透促进剂的种类和用量。方法以大鼠腹部皮肤为透过介质,采用改良Franz扩散池法,以止痛贴膏中主要有效成分欧前胡素的累积透过量为指标,对多种不同配比、不同用量的渗透促进剂进行对比实验。结果 5%处方量的氮酮-NMP(1∶1)作为渗透促进剂,欧前胡素的皮肤透过量最高。结论渗透促进剂的种类、用法及用量均对止痛贴膏中有效成分的透皮量有较大的影响,应充分优化选择。Objective To screen the types and dosage of penetration enhancers in prescription of Zhitong Emplastrum. Methods The abdominal skin of rats was taken as penetration medium, improved Franz diffusion cell method was applied and the active principle of Zhitong Emplastrum, imperatorin, was taken as the index of cumulative penetration volume, the penetration enhancers with different combination and doses were tested and compared. Results The skin penetration volume of imperatorin was the highest when 5% prescription dose of azone-NMP （ 1 ： 1 ） was taken as penetration enhancer. Conclusion The types, usages and doses have larger influences on the skin penetration volume of active principle in Zhitong Emplastrum, and they should be optimized.

关 键 词：止痛贴膏 渗透促进剂 筛选 

分 类 号：R283[医药卫生—中药学]