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作 者:李国[1] 王建利[1] 陈武[1] 黄柳桓[1] 党玉涛[1] 高江平[1]
机构地区:[1]首都医科大学石景山教学医院北京市石景山医院胸外科,100043
出 处:《中国医药》2012年第12期1515-1516,共2页China Medicine
摘 要:目的评价胸腔镜肺减容术治疗重度慢性阻塞性肺气肿(COPE)的临床疗效和应用价值。方法2006年7月至2011年3月我院胸外科为12例重度COPE患者在胸腔镜下行肺减容术,比较患者手术前后肺功能指标的变化。结果全组术中顺利,无死亡,12例患者均康复出院,呼吸困难明显缓解。术后住院时间8~54d,平均(16±10)d。与术前比较,术后6、12个月第1秒用力呼气量、6min步行距离均增加[第1秒用力呼气容积:(0.97±0.07)、(1.01±0.12)L比(0.68±0.15)L;6min步行距离:(380±65)、(415±70)m比(225±70)m],肺总量及残气量均减少[肺总量:(6.3±1.1)、(6.1±1.2)L比(7.8±0.8)L;残气量:(3.6±0.6)、(3.3±0.5)L比(5.2±0.6)L],差异均有统计学意义(均P〈0.05)。结论胸腔镜下肺减容术治疗重度COPE患者近期疗效确切,创伤小,肺功能恢复快,临床上实施切实可行。Objective To evaluate the efficacy and value of application of lung volume reduction surgery treating severe chronic obstructive pulmonary emphysema (COPE). Methods All 12 patients with COPE treated with lung volume reduction surgery (LVRS) were retrospectively analyzed. The lung function indexes of patients before LVRS, half a year and 1 year after LVRS were analyzed. Results All 12 patients recovered and were discharged from hospital. The time of hospitalization was 8-54 days [ mean time: (16 ± 10) days]. Compared to before operation, the forced expiratory volume in one second (FEV1), and 6-minute walk distance (6MWD) of patients with COPE were increased 6 months and 1 year after operation [ FEV1 : (0.97 ±0.07) , ( 1.01 ±0.12) L vs (0.68±0.15)L;6MWD: (380±65), (415 ±70)m vs(225 ±70)m], and total lung capacity(TLC) and residual volume (RV) significantly reduced [TLC:(6.3±1.1), (6.1 ±1.2)L vs(7.8±0.8)L;RV:(3.6±0.6), (3.3 ±0.5)L vs(5.2 ±0.6)L] (all P 〈0.05). Conclusions The lung volume reduction surgery is feasible, minimally invasive and provides rapid recovery of pulmonary function for severe COPE.
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