疫苗不良反应473例报告分析  

Report and analysis of 473 adverse reaction cases of vaccine

作　　者：肖敏[1] 蔡德[2] 林燕[2] 莫姿丽 

机构地区：[1]东省汕头市疾病预防控制中心,515041 [2]汕头大学医学院第一附属医院药剂科 [3]汕头市药检所

出　　处：《中国医药》2012年第12期1615-1617,共3页China Medicine

摘　　要：目的了解疫苗不良反应（ADR）的发生情况。方法对汕头市不良反应中心提供的广东省2006-2009年473例疫苗ADR报告中患者的年龄、ADR的类型、临床表现及涉及系统等信息进行统计分析。结果共涉及疫苗种类24个品种，以吸附无细胞百日咳、白喉、破伤风联合疫苗构成比最大，为22．0％（104／473）；发生于各个年龄段，1个月-3岁构成比较高，达275例，占58．1％（275／473）；ADR类型以一般反应为主，涉及多个系统／器官损害；临床表现以全身胜损害、皮肤及其附件损害占最大比例，分别为31．4％（255／811）和18．4％（149／811）。结论疫苗ADR的发生情况以一般反应为主，其绝大多数经常规处理后可好转或康复，死亡和后遗症发生较少，但仍应引起重视，做好安全接种及不良反应监测工作。Objective To investigate the adverse reactions of vaccine. Methods The report of 473 adverse reaction cases of vaccine from 2006 to 2009 was provided by the Adverse Reaction （ADR） Center of Shantou City. Some information of the report such as the age, types of ADR, clinical Manifestation as well as vaccine-immune system were analyzed. Results There were 24 kinds of vaccine involved in ADR, and the DPT vaccine contributed to the highest proportion C22.0% （104/473） 2. Adverse reaction occurred in all age groups and the 3-5 age group had 275 cases which accounted for a high proportion （58.1%）. The general reactions were the main type of ADR, including the damage of many systems/organs. The main clinical manifestation was systemic lesions （ 31.4% ） , as well as skin damage（ 18.4% ）. Conclusions General reaction is the main type of ADR and most of the patients can recover or be improved. However, attention should be paid to the safe vaccination and the surveillance of ADR.

关 键 词：疫苗 不良反应 

分 类 号：R186[医药卫生—流行病学]