微球-三维支架复合体系控制释放生长因子的研究进展  

Progresses on Composite Systems of Microspheres and Three-dimensional Scaffolds for Controlled Release of Growth Factors

作　　者：唐功文[1] 赵蕴慧[1] 袁晓燕[1] 

机构地区：[1]天津大学材料科学与工程学院,天津市材料复合与功能化重点实验室,天津300072

出　　处：《高分子通报》2012年第12期8-15,共8页Polymer Bulletin

基　　金：国家自然科学基金项目(51073117)

摘　　要：将载生长因子的微球和组织工程三维支架复合得到的微球-三维支架复合体系,能够实现多种生长因子的依次释放和连续释放,满足新组织形成过程中不同阶段对不同量的各种生长因子的需求。在综述了微球和支架作为载体的载生长因子方法及优缺点的基础上,评述了微球-三维支架复合体系的三种制备方法,即自上而下法、复合溶结法和直接混和法,归纳和总结了国内外对微球-三维支架复合体系的研究现状和进展。并阐述了微球-三维支架复合体系的释放机理,指出了微球-三维支架复合体系在理想组织修复中的发展潜力和面临的挑战。Composite systems of microspheres and three-dimensional scaffolds obtained by combining growth factor- containing microspheres and three-dimensional tissue engineering scaffolds can spatiotemporally and sequentially control release of various growth factors, meeting the need of different growth factors at different stages of new tissue formation. In this paper, the preparation methods of microsphere-scaffold systems are summarized based on the merits and drawbacks of microspheres and scaffolds for growth factor-release carriers. Three methods are included, i. e. , bottom up, post- seeding method and directly incorporating method. Research progresses and developments in the composite systems of microspheres and three-dimensional scaffolds for controlled growth factor release in ideal tissue regeneration are reviewed in detail. The drug release mechanism, challenges and development potential of the composite systems of microspheres and three-dimensional scaffolds are also mentioned.

关 键 词：微球 组织工程支架 微球-三维支架复合体系 生长因子 控制释放 

分 类 号：R318.08[医药卫生—生物医学工程]