美吡哒对糖尿病大鼠血流变的影响  

EFFECTS OF CIPROFLOXACIN ON HARMACOKINETICS OF GLOPIZIDE

作　　者：贾志凡[1] 王维力[2] 翁福海[3] 张春时[1] 

机构地区：[1]天津市环湖医院内科,天津300060 [2]天津医科大学总医院内分泌科,300052 [3]天津医科大学药理教研室,300070

出　　处：《中国血液流变学杂志》2000年第2期101-103,共3页Chinese Journal of Hemorheology

摘　　要：采用６只ＳＤ雄性大鼠，经四氧嘧啶制作糖尿病模型成功后，检测其血浆粘度为１．６２ｍＰａ·ｓ，还原粘度为１１．４１，红细胞压积为４８％，经美吡哒治疗后的血浆粘度为 １． ５ｍＰａ·ｓ，还原粘度为９．７，红细胞压积为 ３６％，较治疗前有明显改善，差异具有显著性（ｐ＜０．０５）。提示美吡哒可明显改善糖尿病大鼠血液流变性。The diabetic model of six SD rats was induced by alloxan Before suing glipizide, the serum viscosity was 1 .62, deacidizing viscosity was 1 .41 and hematocrit was 0.48. After using glipizide, the serum viscosity was 1. 5, deacidizing viscosity was 9 .7, hematocrit was 0. 36, and all had significant difference. Conclusion: Glipizide can improve the parameters of hemorheology alone n diabetic rats significantly.

关 键 词：美吡哒 药物疗法 血液流变学 糖尿病 大鼠 

分 类 号：R587.105[医药卫生—内分泌] R331.1[医药卫生—内科学]