TH_5对雄性大鼠性行为与血清性激素水平影响的研究  

Study of Effect on The Sex Behavior and Sex Serum Hormone Level with TH_5 in Male Rats

作　　者：周激文[1] 李文琦[1] 潘汝能 刘黎闻 李欣[1] 张宪民[2] 罗宁云 

机构地区：[1]云南省计划生育技术科学研究所,昆明650021 [2]中科院昆明植物研究所

出　　处：《标记免疫分析与临床》2000年第2期81-83,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为了开发避孕新药 ,本文报告昆明山海棠提取物TH5对Wistar成年雄性大鼠抗生育试验性行为的影响 ,并测定血清性激素水平。灌服TH5( 116mg/kg/d ,共 30d)的雄性大鼠与成年雌性大鼠合笼后 ,其阴栓与阴道涂片精子检出率及服药雄鼠的血清T、LH、FSH测定值 ,和对照组相比均无统计学差异 (P >0 .0 5) ,表明受试雄鼠服用TH5后 。It is observed that the sex bevavior and serum hormone contraception of adult male rats in the antifertility tests after given OP with TH 5 (116mg/kg/d,×30d.) extract from Tripterygium hypoglaucum (Lev1.) Hutch.Results show that positive vaginal plug and sperm are found as well as assay of serum T、LH and FSH in rats of experiment groups, there are all no differnce compared to contral groups (P>0.05).It is possible TH 5 does not distrurbe the sex behavior and sex serum hormone level of male rats after administered TH 5.

关 键 词：TH5 雄性大鼠 性行为 性激素 避孕药 

分 类 号：R392.11[医药卫生—免疫学]