原发性高血压患者血浆甲状旁腺高血压因子的变化  

Study on parathyroid hypertensive factor of essential hypertensive patients

作　　者：张世联[1] 王薇[1] 朱文萍[1] 胡晓东[1] 赵睿珊[1] 

机构地区：[1]河北省医学科学院生化研究室,石家庄050021

出　　处：《临床心血管病杂志》2000年第6期251-252,共2页Journal of Clinical Cardiology

基　　金：河北省重点医学科研课题!No.98027

摘　　要：目的 :观察原发性高血压 (EH)患者血浆甲状旁腺高血压因子 (PHF)活性的变化。方法 :采用生物活性测定方法 ,检测了 31例 EH患者 (EH组 )和 33例正常人 (对照组 )血浆中 PHF活性。结果 :EH组血 PHF平均活性显著高于对照组 (P <0 .0 5～ 0 .0 1) ,其升压模式与自发性高血压大鼠血 PHF活性相似。结论 :检测 PHF对研究 EH病因以及采取有效治疗措施具有重要意义。Objective:To study the parathyroid hypertensive factor (PHF) activity in the plasma of essential hypertensive(EH) patients. Method:The activities of PHF in plasma of 31 EH patients and 33 healthy controls were measured by bioassay. Result:The mean PHF level in 32 EH patients was higher than the healthy control group (P< 0.05 ~ 0.01 ). The model of raising blood pressure with dialyzed plasma of EH patients was similar with the PHF in SHR.Conclusion:Part of hypertensive patients has abnormal PHF activity.

关 键 词：甲状旁腺高血压因子 原发性高血压 PHF 

分 类 号：R544.102[医药卫生—心血管疾病]