龙凤宝片治疗围绝经期综合征的再评价研究  

Re-evaluation of Longfengbao Tablets for Treatment of Perimenopausal Syndrome

作　　者：曹秀梅[1] 潘玉华[1] 

机构地区：[1]承德医学院附属医院药剂科,河北承德067000

出　　处：《中国实验方剂学杂志》2012年第24期324-326,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对龙凤宝片治疗围绝经期综合征(肾阳虚证)的临床疗效与安全性进行评价。方法:84例患者随机分为治疗组和对照组各42例。对照组口服利维爱,2.5 mg/次,1次/d;治疗组口服龙凤宝片,1.2 g/次,3次/d。两组疗程均为12周。观察患者Kupperman评分,测定血清雌二醇(E2)、卵泡刺激素(FSH)及黄体生成素(LH)水平,测定子宫内膜厚度及中医临床症状积分。结果:治疗后两组Kupperman评分及肾阳虚证积分均明显降低(P<0.01),治疗组肾阳虚证积分低于对照组(P<0.01);治疗后两组血清E2水平明显升高(P<0.01);治疗组总有效率88.09%,对照组为92.85%,两组疗效相当;两组治疗后子宫内膜厚度变化不明显。治疗组未见明显不良反应。结论:龙凤宝片能明显改善围绝经期综合征(肾阳虚证)的临床症状,降低Kupperman评分,升高血清E2水平,不增加子宫内膜厚度,临床使用安全有效。Objective： To re-evaluate the clinical efficacy and safety of Longfengbao tablets for the treatment of perimenopausal syndrome. Method： Eighty-four patients were randomly divided into treatment group and control group （n =42 each）. The control group was treated with livial 2.5 mg daily; the treatment group was orally given Longfengbao tablets 1.2 g tid. The treatment lasted for 12 weeks. Kupperman score, serum estradiol （ E2） , follicle stimulating hormone （ FSH）, luteinizing hormone （LH） 1, endometrial thickness were measured and traditional Chinese medicine clinical symptom score were compared between the two groups. Result： After the treatment, the two sets of the Kupperman ratings and deficiency syndrome integral were significantly lowered than before （P 〈0.01 ）, the deficiency syndrome points of the treatment group was lower than that of the control group （P 〈 0.01 ）. Serum E2 level in two groups was significantly increased after treatment （P 〈 0.01 ）. The effective rate of the treatment group was 88.09% while the control group was 92.85% ; the endometrial thickness did not change significantly after the treatment in both groups. The treatment group showed no adverse reactions. Conclusion： Longfengbao tablets can significantly improve the clinical symptoms of perimenopause syndrome, reduce the Kupperman score, elevated serum E2 levels without increasing endometrial thickness, and it is safe and effective.

关 键 词：围绝经期综合征 龙凤宝片 雌二醇 再评价 

分 类 号：R287[医药卫生—中药学]