脂质体冻干因素研究概况  

Progress in Influence Factors of Freeze-dried Liposomes Preparation

作　　者：王立华[1] 王永利[1] 黄慧婷[1] 张江伟[2] 张丹参[3] 

机构地区：[1]河北北方学院应用化学研究所,河北张家口075000 [2]中国石油大学(北京)提高采收率研究院,北京102249 [3]河北北方学院基础医学院,河北张家口075000

出　　处：《中国实验方剂学杂志》2012年第24期371-374,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省科学技术研究与发展计划项目(12276104D-94);河北北方学院自然科学青年基金项目(Q201112)

摘　　要：对制备冻干脂质体过程中的影响因素方面研究进行了文献整理和分析。以冻干脂质体为主题词,在中国学术文献总库(CNKI)中收集冻干脂质体制备方面的文献,根据其相关性引用了35篇文献,对冻干脂质体制备过程中的影响因素进行了归纳和总结。结果显示冻干脂质体制备过程中冻干保护剂及用量、预冻方式及速度、冻干真空度、干燥时间、水化介质等因素影响冻干脂质体质量。综上制备冻干脂质体过程中必须考虑好各种因素才能制备出包封率高、稳定性好、粒径变化小的药物脂质体。应用冻干技术可防止药物氧化、延长药物脂质体保质期,为脂质体药物的推广应用奠定了基础。To conduct a literature review and analysis on the influencing factors in the process of the preparation of freeze-dried liposomes. Using freeze-dried liposome as the subject term to collect literature on freeze-dried liposome preparation aspects in the Chinese academic literature library （ CNKI）, according to its correlation cited 35 articles, and concluded and summarized the influencing factors during the preparation process. The kinds and dosage of protective agent, ways of pre-freezing and speed, the degree of vacuum, drying time, hydration medium and other factors will affect the quality of the freeze-dried liposomes. In the process of preparation of freeze-dried liposomes, a variety of factors must particle size changes. be taken into account to prepare liposomes of a high Application of freeze-drying technology can preve encapsulating rate, high stability and small nt drug oxidation, prolong drug liposome guarantee period, and lay a solid foundation for the promotion and application of liposome drug.

关 键 词：冷冻干燥法 冻干脂质体 制备 稳定性 

分 类 号：R283.5[医药卫生—中药学]