成人隐匿性自身免疫性糖尿病的临床特点分析  

Clinical characteristics of latent autoimmune diabetes mellitus in adults

作　　者：叶景璐[1] 潘天荣[1] 杜益君[1] 钟兴[1] 

机构地区：[1]安徽医科大学第二附属医院内分泌科,合肥230601

出　　处：《安徽医学》2012年第11期1470-1472,共3页Anhui Medical Journal

摘　　要：目的探讨LADA患者与T2DM、急性起病的T1DM患者临床特点的差异。方法比较45例LADA患者与34例T1DM患者和64例T2DM患者的临床生化特点及并发症情况。结果 LADA组的起病年龄显著高于T1DM组,自发酮症的比例高于T2DM组;血糖水平显著高于T2DM组;C肽水平明显低于T2DM组,而与T1DM组无显著差异。在微血管并发症上,LADA组与T2DM组无显著差异,糖尿病神经病变的发病率高于T1DM组,合并高脂血症、脑梗死、心肌梗死者同T2DM组无显著差异;合并高血压病者LADA组明显低于T2DM组。结论 LADA患者在血糖水平、胰岛功能、糖尿病慢性并发症及合并症方面同T2DM及急性起病的T1DM存在差异。Objective To explore the difference of clinical characteristics between the latent autoimmune diabetes in adults and type 2 diabetes mellitus/type 1 diabetes mellitus.Methods In this study,45 latent autoimmune diabetes in adults（LADA）,34 type 1 diabetic patients（T1DM） and 64 type 2 diabetic patients（T2DM） were recruited and their clinical characteristics were compared.Results LADA patients had such characteristics listed as follows： the average age diagnosed as diabetes in LADA patients was older than that in T1DM.The proportion of ketosis in LADA patients was higher than that of T2DM patients.The plasma level of glucose was higher than that of T2DM patients.The level of C-peptide was lower than that of T2DM patients while equal to that of T1DM patients.The proportion of microvascular complications in LADA patients was equal to that in T2DM patients.The proportion of patients combined with hyperlipidemia,cerebral infarction and coronary heart disease was equal to that in T2DM,while the proportion of those with hypertension was lower than that in T2DM.Conclusion There are differences in the clinical characteristics and complications between the latent autoimmune diabetes mellitus in adults and type 2 /type 1 diabetes mellitus.

关 键 词：成人隐匿性自身免疫性糖尿病 1型糖尿病 2型糖尿病 临床特点 

分 类 号：R587.1[医药卫生—内分泌]