氧化苦参碱对自发性高血压大鼠血流动力学的影响  

Effects of oxymatrine on hemodynamic parameters in spontaneously hypertensive rats

作　　者：黄小燕[1] 姜法铭[2] 董炤[1] 王坤[1] 陈长勋[1] 

机构地区：[1]上海中医药大学药理教研室,上海201203 [2]上海市浦东新区动物疫病预防控制中心疫情测报科,上海201202

出　　处：《上海中医药杂志》2012年第12期67-69,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：中国博士后科学基金面上资助项目(20100470725)

摘　　要：目的探讨氧化苦参碱(OMT)对自发性高血压大鼠(SHR)血流动力学的影响。方法 10周龄WKY为正常对照组(A组)和正常给药对照组(B组),分别灌服0.9%NaCl溶液或氧化苦参碱小剂量(30μg/g)。另取10周龄SHR,随机分为4组,每组10只:SHR对照组(C组),给予0.9%NaCl溶液;西药阳性对照组(D组),每日灌服卡托普利40μg/g;治疗组(氧化苦参碱小、大剂量组),给予氧化苦参碱30、60μg/g(E组、F组)。连续给药21周。分别于给药前1周,给药后每隔2周测定1次血压。给药结束后,导管经颈总动脉插入左心室测量左心室收缩压(LVSP)、左室舒张末期压(LVEDP)、左室收缩/舒张最大速率(±dp/dtmax)等血流动力学指标。结果与WKY正常对照组比较,WKY正常给药对照组各指标差异无统计学意义(P>0.05)。与WKY正常对照组比较,SHR对照组收缩压(SBP)、舒张压(DBP)、LVEDP升高,±dp/dtmax降低,差异有统计学意义(P<0.05);LVSP差异无统计学意义(P>0.05)。与SHR对照组比较,氧化苦参碱小、大剂量组及西药阳性对照组在给药后3～18周时SBP、DBP降低(P<0.05);氧化苦参碱大剂量组和西药阳性对照组LVSP升高,LVEDP降低(P<0.05);氧化苦参碱小、大剂量组和西药阳性对照组±dp/dtmax升高(P<0.01)。结论 OMT能降低SHR的血压,改善左心室收缩和舒张功能,对SHR心室重构、心力衰竭的发展有一定的抑制、延缓作用。Objective To explore the effects of oxymatrine（OMT） on hemodynamic parameters in spontaneously hypertensive rats（SHR）.Methods SHRs were divided into four groups,ten rats in each group： SHR control,SHR ＋ 40 mg/kg captopril,SHR ＋ 30 mg/kg OMT,SHR ＋ 60 mg/kg OMT.Normotensive age-matched WKY rats were assigned into two groups： WKY control,WKY＋ 30 mg/kg OMT.The rats were orally administered with the corresponding drugs or drinking water for 21 weeks.Systolic blood pressure（SBP） and diastolic blood pressure（DBP） were measured by tail cuff every three weeks.At the end of this test,the left ventricular systolic pressure（LVSP）,left ventricular end diastolic pressure（LVEDP） and the maximal rate of rise and fall of the ventricular pressure（±dp/dtmax） were recorded.Results Oxymatrine reduced the SBP and DBP,decreased LVEDP,and raised LVSP and ±dp/dtmax.Conclusion Oxymatrine can lower blood pressure in SHRs and ameliorate the diastolic and systolic function to postpone the process of ventricurlar remodeling and heart failure.

关 键 词：氧化苦参碱 自发性高血压大鼠 血流动力学 

分 类 号：R285.5[医药卫生—中药学]