冠心病人同型半胱氨酸水平的主要影响因素  

Main factors influencing plasma homocysteine level in patients with coronary heart disease

作　　者：洪涛[1] 高炜[1] 朱国英[1] 霍勇[1] 姜宁[1] 蒋捷 

机构地区：[1]北京医科大学第一医院,100034

出　　处：《中华内科杂志》2000年第6期392-394,共3页Chinese Journal of Internal Medicine

基　　金：卫生部基金!( 98 1 2 5 1)

摘　　要：目的　分析影响冠心病人血浆同型半胱氨酸水平的主要非遗传因素。方法　 16 4例住院冠心病患者 ,测定血浆同型半胱氨酸水平并分析其与血浆及全血叶酸、血浆维生素B12 、血清雌二醇浓度以及冠心病传统危险因素之间的关系。结果　血浆同型半胱氨酸水平与叶酸、维生素B12 水平呈负相关 ,男性血浆同型半胱氨酸浓度高于女性 [(2 0 74± 13 42 )× 10 -6mol/L比 (15 5 6± 8 16 )× 10 -6mol/L ,P <0 0 5 ],吸烟者高于不吸烟者 [(2 2 2 9± 15 18)× 10 -6mol/L比 (17 2 1± 9 5 4)× 10 -6mol/L ,P <0 0 5 ]。结论　叶酸、维生素B12 。Objective To analyze the main non hereditary factors influencing plasma homocysteine level in patients with coronary heart disease. Methods Blood was taken from 164 patients for plasma homocysteine estimation. The relationships between plasma homocysteine level and plasma and whole blood folic acid, plasma vitamin B 12 , serum estradiol, and traditional risk factors for coronary heart disease were assessed. Results Plasma homocysteine level was negatively related to plasma and whole blood folic acid and plasma vitamin B 12 . Plasma homocysteine level was higher in male than in female [(20.74±13.42) ×10 -6 mol/L vs (15.56±8.16) ×10 -6 mol/L, P <0.05], and higher in smokers than in non smokers [(22.29±15.18) ×10 -6 mol/L vs (17 21±9.54)×10 -6 mol/L, P <0.05]. Conclusion Folic acid and vitamin B 12 levels, sex and smoking were the main non hereditary factors influencing plasma homocysteine level in patients with coronary heart disease.

关 键 词：同型半胱氨酸 叶酸 维生素B12 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]