驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用  

Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro

作　　者：刘鸿越[1] 江键[2] 马琳[2] 梁媛媛[2] 董法杰[2] 崔黎丽[1] 

机构地区：[1]第二军医大学药学院无机化学教研室,上海200433 [2]第二军医大学基础部数理教研室,上海200433

出　　处：《药学实践杂志》2012年第6期440-442,466,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金资助(50977089);上海市自然科学基金资助(10ZR1437600)

摘　　要：目的研究驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用。方法采用常温电晕充电的-500V,-1 000 V、-2 000 V聚丙烯为驻极体,1%、3%、5%的氮酮为化学促渗剂,利用透皮实验仪和HPLC,研究驻极体、氮酮以及驻极体联用氮酮对环孢菌素A溶液的透皮促渗作用。结果不同表面电压的驻极体以及不同浓度的氮酮均能提高环孢菌素A的累积渗透量;-1 000 V驻极体与1%氮酮联用,环孢菌素A的累积渗透量较1%氮酮单独使用略有提高。结论负极性驻极体、氮酮对环孢菌素A均有促渗作用,负极性驻极体与氮酮联用对环孢菌素A没有明显联合促渗作用。Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde liv- ery in vitro. Methods Using corona charged -500 V, - 1 000 V and -2 000 V polypropylene （PP） as electrets, 1% , 3% and 5% Azone as chemical enhancers, the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method. The concentration of cyclosporine A was measured by HPLC. Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug. The combination of - 1 000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone. Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually. But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery.

关 键 词：驻极体 环孢菌素A 氮酮 透皮吸收 透皮促进作用 

分 类 号：R94[医药卫生—药剂学]