百蕊草对阿霉素肾病大鼠治疗作用的实验研究  

Therapeutic effects of Thesium chinensis on adriamycin-induced nephropathy rats

作　　者：宣伟东[1] 唐大海[1] 卞俊[1] 胡水根[1] 胡建峰[1] 范正平[1] 

机构地区：[1]解放军第411医院药学科,上海200081

出　　处：《药学实践杂志》2012年第6期443-446,共4页Journal of Pharmaceutical Practice

基　　金：上海市卫生局局级科研课题(2012085号)

摘　　要：目的观察百蕊草对大鼠肾病综合征的治疗作用。方法 SD大鼠40只,10只为空白对照组,余下分为模型组,低剂量组(1.0 g/(kg.d)),高剂量组(5.0 g/(kg.d)),每组10只,尾静脉注射阿霉素6.0 mg/kg建立肾病模型。连续灌胃给药5周,观察百蕊草对肾病大鼠尿量、24 h尿蛋白、血液生化指标、肾组织病理学等方面的影响。结果百蕊草能够减轻ADR大鼠肾病综合症烂尾、水肿等症状。与模型组相比,百蕊草治疗第2周以后,尿量显著增加(P<0.01),治疗3周后,24 h尿蛋白浓度下降(P<0.05),低剂量组尿蛋白浓度显著下降(P<0.01)。治疗5周后,低剂量组的血清总蛋白(TP)、血清蛋白(ALB)水平显著高于模型组(P<0.01),总胆固醇(TCH)、甘油三酯(TG)水平则显著降低(P<0.01)。结论百瑞草具有利尿、消除水肿、降低尿蛋白、降血脂、提高血清蛋白等作用,改善病理组织学变化,减轻肾脏损害,对肾病综合征大鼠具有良好的治疗效果。Objective To investigate the therapeutic effects of Thesium chinensis Turcz on Adriamycin-induced nephropathy rats. Methods 40 SD rats were divided into 4 groups averagely： normal control group, model control group, low-dosage group （ 1.0 g/（ kg · d） and high-dosage group（5.0 g/（ kg · d）. Nephritic syndrome models were established in 30 rats by intravenous injection of Adriamycin （6.0 mg/kg ）. The rats of low-dosage group and high-dosage group were intragastric administrated decoction of Thesium chinensis Turcz daily, the model control group rats were given running water（2 ml）. During 5 weeks treatment process, the 24 hour u- rine volume, 24 hour urine protein concentration of rats were observed. The level of total serum protein（TP） , serum albumin（ALP） , total cholesterol（TCH） , triglycerides（TG） and UREA were determined, and the pathological changes of kidney tissue were assayed af- ter the therapy process. Results The symptoms of nephritic syndromes, such as edema, tail-rot disease, were relieved by Thesium chinensis Turcz. After 2 weeks therapy, the 24 hour urine volume of low-dosage group and high-dosage group were significantly higher than model control, and the 24 hour urine protein concentration were significantly lower than model control afler 3 weeks. The level of TP and ALP of low-dosage group were significantly higher than model control, as well as the level of TCH and TG were significantly lower after 5 weeks. Conclusion Thesium chinensis Turcz could eliminate tissue edema and decrease the urine protein concentration by diuretic action and improves renal pathology to protect the kidney from damage by reducing the serum cholesterol level, decreased blood lipid content, and increased the plasma protein level. [

关 键 词：百蕊草 药效学 阿霉素肾病 SD大鼠 中药治疗 

分 类 号：R965[医药卫生—药理学]