IMSAOPP患者血清NSE和S-100β蛋白的变化及意义  

CHANGES AND SIGNIFICANCE OF NSE AND S-100β PROTEIN IN SERUM OF INTERMEDIATE SYNDROME AFTER ACUTE ORGANOPHOSPHORUS PESTICIDE POISONING PATIENTS

作　　者：霍永生[1] 王伟华[1] 蒋静涵[1] 汪利宗[1] 

机构地区：[1]皖南医学院附属弋矶山医院急诊内科,安徽芜湖241000

出　　处：《承德医学院学报》2012年第4期367-369,共3页Journal of Chengde Medical University

摘　　要：目的:观察急性有机磷农药中毒后中间综合征(IMSAOPP)患者血清神经元特异性烯醇化酶(NSE)和脑特异性蛋白(S-100β)的变化及意义。方法:15例健康体检者为正常对照组,15例急性有机磷农药中毒后不伴有中间综合征患者为病例对照组,15例IMSAOPP患者为病例组,检测各组血清NSE和S-100β水平。结果:病例组患者血清NSE和S-100β水平明显高于病例对照组和正常对照组(P<0.05)。结论:血清NSE和S-100β含量与IMSAOPP病情相关,可作为判断病情、评估预后的重要指标。Objective：To investigate the changes and significance of neuron specific enolase（NSE） and S-100β protein level in serum of intermediate syndrome after acute organophosphorus pesticide poisoning（IMSAOPP） patients.Methods：Acute organophosphorus pesticide poisoning patients were divided into two groups： case control group of 15 patients without intermediate syndrome,case group of 15 patients with intermediate syndrome after acute organo phosphorus pesticide poisoning.And 15 healthy controls were taken as normal control group.The NSE and S-100β protein level in serum of patients were detected respectively.Results：The NSE and S-100β protein level in serum of patients of case group were obviously higher than that in case control group and normal control group（P0.05）.Conclusions：The NSE and S-100β protein level in serum relate to the state of IMSAOPP,and can be acted as indexes to judge state and prognosis of IMSAOPP.

关 键 词：急性有机磷农药中毒后中间综合征 神经元特异性烯醇化酶 S-100Β蛋白 

分 类 号：R446.62[医药卫生—诊断学]