阿柔比星A聚乳酸毫微粒冻干针剂小鼠体内分布研究  

Study on the distribution of aclarubicin A poly lactide nanoparticle lyophilization in mice

作　　者：何林[1] 蒋学华[2] 

机构地区：[1]四川省人民医院药剂科,成都610072 [2]华西医科大学药学院,成都610041

出　　处：《中国抗生素杂志》2000年第3期214-217,共4页Chinese Journal of Antibiotics

基　　金：国家自然科学基金!资助项目 (合同号 39570 842 );国家医药技术创新博士项目! (合同号 95- B- 0 9)

摘　　要：对阿柔比星 A冻干针剂与阿柔比星 A(ACRB- A)聚乳酸毫微粒冻干针剂给予小鼠尾静脉注射后体内分布进行比较。采用 HPL C法分别测定小鼠给药后血液及主要脏器中 ACRB- A浓度。结果 ,阿柔比星A聚乳酸毫微粒在小鼠肝脏中的浓度高于对照品浓度。提示阿柔比星 A制成毫微粒后可显著提高肝脏靶向性。Objective: Comparing the distribution of aclarubicin A lyophilization and aclarubicin A poly lactide nanoparticle (ACRB A PLA NP) lyophilization in mice. Method: HPLC is selected to determine the concentration of aclarubicin A in plasma and in main organisms. Results: The concentratin of ACRB A PLA NP in liver is higher than that of the reference. Conclusion: ACRB A can be significantly concentrated in liver after prepared in nanoparticle.

关 键 词：阿柔比星A 聚乳酸毫微粒 体内分布 冻干针剂 

分 类 号：R979.14[医药卫生—药品]