SPIO结构,功能及应用浓度研究新进展  

Advances in Superparamagnetic Iron Oxide: Structure,Function and Application Concentration

作　　者：吕鑫[1] 赵志杰[2] 吴江[1,2] 

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830011 [2]河北医科大学临床学院,石家庄050017

出　　处：《四川解剖学杂志》2012年第3期30-32,共3页Sichuan Journal of Anatomy

基　　金：国家自然科学基金项目(10802054;11262020);新疆维吾尔自治区自然科学基金项目(201233146-9)资助

摘　　要：超顺磁性氧化铁(SPIO)具有典型的晶体结构,有效成分是Fe3O4晶体核心,其作为纳米粒子,常包被葡聚糖右旋糖酐或其他物质而具有一定的水溶性或生物活性。Fe3O4具有极强铁磁性和超顺磁性,能缩短周围氢质子的弛豫时间,降低正常组织的信号强度,使T2加权图像信号明显下降,SPIO因能被网状内皮系统所摄取而已被用作临床磁共振成像(MRI)T2加权造影剂;同时,SPIO也可被组织中不同类型细胞所摄取的浓度的不同而显示出不同的影像学差异,因此SPIO的应用浓度对细胞的活性及MRI效应有着重要的影响。本文就相关进展做一综述。Superparamagnetic iron oxide（SPIO） is a typical crystalline magnetite structure with Fe3O4 nucleus.In order to enhance its soluble and bioactive behavior,SPIO usually is coated with dextran or dextran derivatives.Fe3O4 has extremely strong ferromagnetic and superparamagnetism,can shorten hydrogen macroscopic nuclear relaxation time and reduce the T2 signals of absorbing tissues when injected as contrast agent during imaging.SPIO contrast agents have been used successfully in some instances for T2 weighted magnetic resonance imaging（MRI） when phagocyted by cells of the reticuloendothelial system.Nevertheless,there may show different imaging because SPIO uptake in various cells of tissue,thereby SPIO concentration is significant to both cellular activity and MRI imaging demonstration.The article is to summarize the progress of the researches on structure,function and application concentration of SPIO in recent years.

关 键 词：超顺磁性氧化铁 磁共振成像 对比剂 纳米粒子 

分 类 号：R310[医药卫生—基础医学]