酮咯酸氨丁三醇联合曲马多超前镇痛预防小儿全麻苏醒期躁动的临床观察  

Clinical observation of preemptive effect of tramadol combined with ketorolac tromethamine on emergence agitation in children

作　　者：田悦[1] 郭善斌[2] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004 [2]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《实用药物与临床》2012年第11期709-710,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨酮咯酸氨丁三醇联合曲马多超前镇痛预防小儿全麻苏醒期躁动的作用。方法选择40例择期在全麻下行骨折闭合复位的患儿,随机分为联合用药组和对照组,每组20例。对照组在全麻诱导前静注曲马多0.8 mg/kg,联合用药组在全麻诱导前静注酮咯酸氨丁三醇0.5 mg/kg和曲马多0.8 mg/kg。术中监测血压、心率、血氧饱和度、呼吸末气体浓度,记录手术时间、麻醉时间、拔管时间及术后躁动情况。结果两组患儿手术时间、麻醉时间、拔管时间、术后低氧血症、恶心呕吐发生率的差异均无统计学意义(P>0.05),联合用药组术后躁动发生情况优于对照组(P<0.05)。结论酮咯酸氨丁三醇联合曲马多预防小儿全麻苏醒期躁动的疗效优于单用曲马多,值得临床借鉴。Objective To evaluate the preemptive effect of tramodol combined with ketorolac tromethamine on agitation during recovery from anesthesia in children.Methods Forty children who were scheduled for closed reductions were randomly divided into combination group（n=20）in which preemptive analgesia was produced by ketorolac tromethamine 0.5 mg/kg combined with tramodol 0.8 mg/kg before anesthesia induction and control group（n=32）in which only tramodol was given before anesthesia.Duration of surgery and anesthesia,PACU staying time,emergence agitation,postoperative adverse effects were recorded.Results There was no significant difference in duration of surgery and anesthesia,PACU staying time and postoperative adverse effects between the two groups（P0.05）.The emergence agitation was obviously improved in combination group compared with control group（P0.05）.Conclusion Preemptive analgesia of tramodol combined with ketorolac tromethamine can reduce emergence agitation in children,and it is superior to using tramodol only.

关 键 词：酮咯酸氨丁三醇 曲马多 躁动 儿童 

分 类 号：R726.1[医药卫生—儿科]