正常月经周期IVF-ET患者助孕情况与睾酮水平的关系  

The Relation Between the Condition of Normal Menstrual Cycle IVF-ET and Testosterone Levels

作　　者：李宇彬[1] 麦庆云[1] 丁晨晖[1] 周灿权[1] 

机构地区：[1]中山大学附属第一医院生殖中心,广州510080

出　　处：《国际生殖健康／计划生育杂志》2012年第6期439-441,共3页Journal of International Reproductive Health/Family Planning

基　　金：国家自然青年科学基金(81100470)

摘　　要：目的:探讨正常月经周期女性在进行体外受精(IVF)周期中其卵巢基础内分泌及助孕周期情况与血清睾酮水平的关系。方法:按一定标准收集2011年3月—2011年7月在中山大学附属第一医院生殖中心行IVF-胚胎移植(ET)治疗的、具有正常月经周期的495例妇女资料。比较患者不同年龄、基础促性腺激素、基础黄体生成激素(LH)、基础卵泡刺激素(FSH)/LH比值、基础雌二醇(E2)分组间的睾酮浓度差别;比较不同血清睾酮水平患者的IVF周期情况。结果:不同年龄、基础FSH/LH比值分组间睾酮差别有统计学意义(均P<0.05);而基础促性腺激素、基础LH、基础E2不同分组间睾酮差别无统计学意义(均P>0.05)。不同睾酮水平组间IVF周期取卵数以及可移植胚胎数差别有统计学意义(均P<0.05)。结论:血清睾酮水平与年龄、FSH/LH比值以及超促排卵取卵数等卵巢储备评估指标有关联。血清睾酮水平对有正常月经周期的女性IVF周期助孕结局也有影响。Objective：To investigate the relation between the serum testosterone level and basis ovarian endocrine and infertility treatment condition during IVF cycles in normal menstrual cycle women. Methods：495 cases who had IVF-ET cycles from March 2011 to July 2011 in our center were collected, Cases were divided into groups with different parameters, such as age, basis FSH, basis LH,FSH /LH ratio,and basis E2. Testosterone levels, and treatment of IVF cycles, were meticulously compared. Results.The testosterone levels were statistically different in those sub-groups which divided with age and basal FSH/LH ratio （P〈0.05）, while they were not statistically different in those sub-groups divided with basis FSH,basis LH,FSH/LH ratio, and basis E2 （P〉0.05）. Among those groups with different testosterone levels,the numbers of retrieval oocyte and portable embryos in the IVF-ET cycles were significantly different （P〈0.05）. Conclnsions：Serum testosterone levels were related to some classic indicators of ovarian reservation,such as age, FSH/LH ratio and oocyte number of super-ovulation. The serum testosterone levels can also influence the IVF-ET treatment results in women with normal menstrual cycle.

关 键 词：睾酮 受精 体外 胚胎移植 卵巢 妊娠结局 月经周期 

分 类 号：R714.8[医药卫生—妇产科学]