卵巢低反应辅助治疗的研究进展  

Adjunctive Therapy for the Poor Ovarian Response

作　　者：吴慧慧[1] 吴隆琦[1] 邵小光[1] 

机构地区：[1]大连市妇产医院生殖中心,116027

出　　处：《国际生殖健康／计划生育杂志》2012年第6期458-461,478,共5页Journal of International Reproductive Health/Family Planning

摘　　要：改善卵巢低反应患者体外受精-胚胎移植(IVF-ET)的妊娠结局对生殖医生来说是巨大的挑战。虽然随着辅助生殖技术(ART)水平的不断提高,人们对卵巢低反应的认识不断增加,但到目前为止,其发病的具体机制仍未明了,且缺乏统一的诊断标准。同时,在改善卵巢低反应患者的IVF-ET周期结局的策略方面存在很大的争议。阐述了改善卵巢低反应者的周期结局的辅助治疗及其新观点,即在不改变控制性促排卵方案的前提下,在促排卵周期或前期添加辅助治疗药物,以改善卵巢低反应患者的IVF-ET的周期结局,如添加生长激素、睾酮、脱氢表雄酮、黄体生成激素、口服避孕药或雌二醇。It is a big challenge to improve the outcome of in vitro fertilization-embryo transplantation （IVF-ET） of poor ovarian responders for reproductive physicians. With the development of assisted reproduction technology （ART）,the knowledge of poor ovarian response was accumulated. However,the etiology was poorly understood. There is no consensus on the diagnosis. Moreover,there is much controversy on the treatment strategy of poor responders. This review provided the current evidence and opinion on adjunctive therapy for the poor ovarian responders. Adjunctive medicine included growth hormone,testosterone,dehydroisoandrosterone, luteinizing hormone,oral contraceptive pills and estradiol during the controlled ovarian hyperstimulation or the previous cycle with the same ovarian stimulation protocol, by which to improve the poor responders＇ outcomes.

关 键 词：排卵诱导 卵巢低反应 受精 体外 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]