双酚A的生殖毒性研究进展  

Effect of Bisphenol A on Embryo Development and Reproductive Function

作　　者：罗建[1] 黄博贤[1] 崔毓桂[1] 

机构地区：[1]南京医科大学第一附属医院生殖医学科,210029

出　　处：《国际生殖健康／计划生育杂志》2012年第6期471-474,494,共5页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(81170559);国家重点基础研究发展计划(973计划)(2012CB944902)

摘　　要：双酚A(Bisphenol A,BPA)作为一种重要的工业原料,广泛存在于塑料制品中。人类通过多种途径接触吸收、并在体内蓄积BPA,职业接触人群和日常生活接触人群的体内BPA水平差别较大,但即使低于安全摄入剂量[50μg(/kg.d)],母体在围生期接触BPA后也会对胚胎发育有影响,成人长时间接触BPA对其生殖系统的健康也会产生作用;影响的程度及范围会随着摄入剂量的增加而增大。因此,提前预防过早过多接触BPA类物质是非常必要的。从BPA的接触途径介绍分析BPA对人体的胚胎期、婴儿期及成年期生殖系统发育的影响,以及不同剂量浓度下产生的影响变化情况,为以后预防和研究方向奠定基础。Bisphenol A （BPA） is widely used in food packaging and beverage material. BPA as one of environmental endocrine disruptors can interfere with human reproductive system and embryo development, even at the low concentration,so-called safe intake dose. Exposure of BPA at perinatal period will affect the embryonic development. Exposure of BPA of adults for a long time will also affect the reproductive health. The more dose of BPA exposure or the longer,the more effect in severity and range. Therefore,it is necessary to prevent BPA exposure at the early stage. We reviewed here the effects of BPA exposure on the development of reproductive system of individuals at different developmental stages, the different effects of different doses of BPA exposure.

关 键 词：胚胎发育 泌尿生殖系统 性腺障碍 双酚A 

分 类 号：R114[医药卫生—卫生毒理学]