母婴配对巨细胞病毒感染的研究  

Study of cytomegalovirus infection in paired mother and infant

作　　者：杨学磊 杜文慧 刘晓红[2] 加娜尔 孙荷 

机构地区：[1]新疆自治区儿科研究所,830001 [2]新疆自治区人民医院儿科

出　　处：《中国实用儿科杂志》2000年第6期355-356,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的　进一步探讨母婴之间巨细胞病毒 (CMV)的感染与传播。方法　对 36对母婴配对的尿和 16例母乳标本进行CMV分离 ,其中 2 6例检测CMVIgM抗体。 结果　婴儿尿CMV分离阳性率为 47 2 % ,其中 1个月内、～ 4个月、～ 1岁婴儿阳性率分别为 0、6 0 0 %和 33 3 % ,存在显著差异 (χ2 =6 5 7,P <0 0 5 )。母亲母乳CMV分离阳性率为 75 % ,显著高于其尿的排毒率 5 6 % (χ2 =2 3 74,P <0 0 1)。在喂养方式中 ,纯母乳喂养儿CMV阳性率为 5 7 7%与非纯母乳喂养儿的 2 0 %相比 ,差异显著 (χ2 =4 12 ,P <0 0 5 )。在不同病种中 ,婴儿肝炎综合征(婴肝 )患儿CMV培养及IgM的阳性率为 5 5 % ,支气管肺炎患儿CMV阳性率则高达 80 % ,而 6例其它病种患儿仅 2例阳性。结论　母乳是婴儿获得CMV感染的主要来源。Objective To investigate the cytomegalovirus(CMV)infection and transmission between mothers and infants.Methods Thirty-six mother-infant pairs'urine and sixteen mothers'breast milk were examined for cytomegalovirus isolation and sera of twenty-six infants for anti-CMV IgM antibody were detected.Results The positive rate of cytomegalovirus isolation in urine of infant was 47 2%,in which,age of <1 month,1～3 months and 4 months to 1 year were zero,60 0% and 33 3%,respectively(χ 2=6 57,P<0 05).CMV culture positive rate in breast milk(75%) was markedly higher than that in urine (5 6%)(χ 2=23 74,P<0 01).In different styles of feeding,there was significant difference of CMV positive rate from infants on breast feeding (57 7%)to those on mixed feeding(20%)(χ 2=4 12,P<0 05).In different diseases,the positive rates of CMV isolation and anti-CMV IgM antibody were 55% in infantile hepatitis syndrome and isolation of CMV was 80% in pneumonitis and only 2 cases were positive in 6 other diseases.Conclusion Breast milk is the major source of CMV infection acquired by infant.Infantile hepatitis syndrome and pneumonitis of the younger are mainly infected by CMV.

关 键 词：巨细胞病毒感染 母婴传播 CMV 抗体 

分 类 号：R714.7[医药卫生—妇产科学] R512.99[医药卫生—临床医学]