^(123)I-epidepride:多巴胺D_2受体显像剂  

^(123)I-epidepride:an imaging agent for dopamine D_2 receptor

作　　者：杨敏[1] 

机构地区：[1]江苏省原子医学研究所,江苏无锡214063

出　　处：《国外医学（放射医学核医学分册）》2000年第2期67-70,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：12 3　 I- epidepride是一种较好的多巴胺 D2 受体 SPECT显像剂 ,其亲和力高 (Kd 为 2 4pmol/L) ,亲脂性相对较低 (lg Kw=2 .0 5 ) ,适于纹状体和纹状体外造影 ,在垂体腺瘤显像中有较高的临床应用价值 ,并可预测一些垂体腺瘤对多巴胺治疗的反应。I epidepride, 123 I (s) N [(1 ethyl 2 pyrrolidinyl) methyl] 5 iodo 2, 3 dimethoxybenzamide,is a potent imaging agent for SPECT of dopamine D 2 receptor. With high affinity ( K d=24pmol/L) and relatively low lipophilicity (lg K w=2. 05 ), it's suitable for imaging in striated and extrastriated. In addition, it has high value in imaging of dopamine D 2 receptors in pituitary adenoma, and it can serve as a predictor for response to dopamine agonist treatment.

关 键 词：^123I-epidepride 多巴胺D2受体显像剂 垂体腺瘤 

分 类 号：R817[医药卫生—影像医学与核医学]