前白蛋白在肺部感染致老年多器官及消化功能不全的变化  

Change of prealbumin in serum of senile patients with multiple organ dysfunction syndrome and impaired digestive function induced by pulmonary infections

作　　者：杨长春[1] 高敏[2] 夏娴[3,4] 赵海滨[5] 

机构地区：[1]武警总医院南楼一科,北京100039 [2]武警总医院感染控制科,北京100039 [3]武警总医院 [4]北京军区总医院感染控制科,北京100700 [5]武警总医院检验科,北京100700

出　　处：《中华医院感染学杂志》2012年第23期5239-5240,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨前白蛋白在肺部感染导致老年多器官功能不全(MODSE)暨消化功能不全患者的变化,为该疾病的诊断及检测提供依据。方法选择肺部感染导致老年多器官功能不全患者100例,其中肝脏及胃肠功能不全患者分别为24、25例,正常对照40名,应用免疫投射比浊法测定血清前白蛋白变化。结果对照组血清前白蛋白水平为(0.28±0.050)mg/L,MODSE组患者为(0.145±0.070)mg/L,其中肝功能不全组、胃肠消化功能不全组血清前白蛋白水平分别为(0.147±0.065)mg/L、(0.124±0.058)mg/L,较对照组明显降低,经统计处理,差异有统计学意义(P<0.05);对照组血清前白蛋白异常比例为0,MODSE组患者血清前白蛋白异常率低于正常比例的78%,肝功能不全组、胃肠功能不全组前白蛋白异常率低于正常的比例分别为83.0%、88.0%,均较对照组明显升高,以胃肠功能不全组更为明显,经χ2检验,差异有统计学意义(P<0.05)。结论前白蛋白参与老年肺部感染导致多器官功能不全病理过程,可作为炎症损伤的及消化功能不全重要标志物。OBJECTIVE To explore the change of prealbumin in the serum of the senile patients with multiple organ dysfunction syndrome（MODSE） and impaired digestive function so as to prouide basis for the dignosis and monitoring of the disease. METHODS A total of 100 patients with MODSE induced by pulmonary infections were selected, including 24 cases of impaired liver function and 25eases of impaired gastrointestinal function, and 40 cases were set as the controls. The levels of prealbumin in the serum were measured by immune projection turbidimetric method. RESULTS The level of serum prealbumin was （0. 145±0. 070） mg/L in the MODSE group and （0.28±0. 050） mg/L in the control group, and the levels of serum prealbumin of the impaired liver function group and the impaired gastrointestinal function group were （0. 147±0. 065）mg/L and（ 0. 124±0. 058） mg/L, respectively, which were significantly lower than those of the control group, the statistical analysis showed that the difference was statistically significant（P〈0.05）. The abnormal ratio of serum prealbumin was 0% in the control group and 78.0%in the MODSE group which was lower than the normal ratio of the serum prealbumin, the abnormal ratios of serum prealbumin were 83.0 % and 88.0 % respectively in the impaired liver function group and gastrointestinal function group, with an significant increase in the abnormal ratio of serum prealhumin as compared with the control group, especially in the impaired gastrointestinal group, X^2 test showed that the difference was statistically significant （P 〈 0. 05）. CONCLUSION These findings indicate that the serum prealbumin may involve in the pathogenesis of MODSE induced by pulmonary infections in the senile patients, which can be regarded as an important.marker of impaired digestive function.

关 键 词：前白蛋白 肺部感染 老年多器官功能不全 变化 

分 类 号：R181.32[医药卫生—流行病学]