3种新型α_1-受体阻断剂的高效毛细管电泳手性分离  

CHIRAL SEPARATION OF THREE NEW ANTAGONISTS OF ALPHA 1-ADRENOCEPTORS BY CAPILLARY ELECTROPHORESIS

作　　者：牛长群[1] 任雷鸣[2] 

机构地区：[1]华北制药集团新药研究开发中心,石家庄050015 [2]河北医科大学药学院药理学研究室,河北石家庄050017

出　　处：《药学学报》2000年第6期451-453,共3页Acta Pharmaceutica Sinica

摘　　要：目的　建立 3种新型α1 受体拮抗剂阿夫唑嗪、特拉唑嗪、多沙唑嗪的手性分离方法。方法　通过探讨环糊精的种类、浓度、缓冲液的浓度、pH值对分离的影响 ,选择手性分离的最佳条件。结果　 3种新型α1 受体阻断剂的光学异构体得到基线分离。AIM To establish new methods for the chiral sepatation of three new drugs, ie, alfuzosin, terazosin and doxazosin. METHODS By optimizing factors which affect the chiral separation, the kinds and concentrations of cyclodextrin, the pH value and the concentration of buffer, the optimum conditions for chiral separation were selected. RESULTS The enantiomers of three new drugs were base line separated. CONCLUSION The newly established method can be used to study the enantiomers of three new drugs.

关 键 词：高效毛细管电泳法 手性分离 α1-受体阻断剂 

分 类 号：R972[医药卫生—药品] R927.2[医药卫生—药学]