脱氢表雄酮对卵巢储备功能降低患者IVF-ET结果的影响  

Dehydroepiandrosterone treatment improves the ovarian response and cycle outcome in the patients with diminished ovarian reserve

作　　者：胡蓉[1] 宋学茹[1] 岳天孚[1] 白晓红[1] 赵晓徽[1] 吕睿[1] 张慧娟[1] 王艳霞[1] 江昌新[1] 

机构地区：[1]天津医科大学总医院生殖医学中心,300052

出　　处：《中国计划生育学杂志》2012年第12期832-835,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨脱氢表雄酮(DHEA)对卵巢储备功能降低(DOR)患者行体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法:对接受体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕治疗的47例DOR患者DHEA辅助治疗前后周期进行自身对照研究,分析卵巢储备功能指标(基础激素水平、窦卵泡计数等)及周期治疗参数(卵泡数、获卵数、受精率、卵裂率、胚胎种植率、临床妊娠率、周期取消率、流产率等)的变化。结果:前后周期超促排卵方案无显著性差异,DHEA辅助治疗后基础窦卵泡计数、卵泡数、获卵数显著增加(P<0.05),卵裂率、胚胎种植率、临床妊娠率显著提高(P<0.05),周期取消率呈降低趋势(P>0.05),而受精率、流产率无差异(P>0.05)。结论:DHEA辅助治疗可以改善DOR患者卵巢储备功能,提高卵巢反应性,改善IVF治疗结局。Objective： To investigate the effect of dehydroepiandrosterone （DHEA） supplementation on in vitro fertilization and embryo transfer （IVF -ET） outcomes among the patients with diminished ovarian reserve （DOR）. Methods： A self- control study was conducted on 47 DOR patients treated with IVF/ICSI from Jan 2007 to Aug 2012 in our center. The parame- ters of ovarian reserve and IVF outcomes between the cycles before and after DHEA treatment were compared, including basal hormone levels, antral follicle count （ AFC）, the number of follicles, the number of oocytes retrieved, fertilization rate, cleav- age rate, implantation rate, clinical pregnancy rate, the cycle cancellation rate and abortion rate. Results： The ovarian stimu- lation protocols were similar between the cycles with and without DHEA treatment. A significant increase was noted in AFC, number of follicles and retrieved oocytes after DHEA treatment （P 〈 0.05）, and cleavage rate, implantation rate and clinical pregnancy rate were improved significantly as well （P 〈 0.05）. There was no significant difference in fertilization rate, abor- tion rate or cycle cancellation rate （P 〉 0.05 ）, but there was a trend towards a reduced cycle cancellation rate after DHEA treatment. Conclusion： DHEA treatment has a beneficial effect on the DOR patients, and could enhance ovarian response and improve the clinical outcome.

关 键 词：脱氢表雄酮 卵巢储备功能降低 卵巢低反应 体外受精-胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]