苦参碱磁性缓释颗粒的制备及性能研究  

Study on preparation and properties of magnetic sustained release granules loaded matrine

作　　者：谢明全[1,2] 张玲玲[1,3] 黄媛梅[1,3] 李平[1,2] 李玉民[1,2] 

机构地区：[1]兰州大学第二医院,甘肃兰州730030 [2]甘肃省消化系统肿瘤重点实验室,甘肃兰州730030 [3]兰州大学药学院,甘肃兰州730000

出　　处：《中国生化药物杂志》2012年第6期706-708,712,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：天津市东丽区人民政府创业苗圃专项资助项目(编号2011DL-LD-0011);甘肃省科技计划项目(No:0708NKCA129);甘肃省消化系肿瘤重点实验室项目(No:lzujbky-2011-t03-07)

摘　　要：目的制备苦参碱磁性缓释颗粒,并对其性能进行研究。方法以壳聚糖、Fe3O4纳米粒为主要材料,采用L9(34)正交试验法优选制备工艺,并评价其性能。结果正交设计获最优处方为:微晶纤维素质量0.40 g,壳聚糖浓度2.0%,壳聚糖质量0.25 g,磁性纳米粒质量为0.12 g,药物体外释放行为符合一级动力学方程,并具有明显的磁敏感性。结论该制剂制备工艺合理可行,有较好的缓释效果和顺磁性,可作为消化系肿瘤治疗的给药剂型。Purpose To prepare the magnetic sustained release granules loaded matrine and to evalu- ate its properties. Methods Using chitosan and Fe3Q nanoparticles as major matrix,the optimal formula- tion of matrine magnetic sustained release granules was selected by L9 （3^4） orthogonal design. Also, its properties were estimated. Results The best recipe was as follows：MCC 0.40 g, chitosan concentration 2.0% ,chitosan 0.25 g and Fe3O4 nanoparticles 0.12 g. The release behavior followed the first-order ki- netics,and occupated significant magnetic sensitive characteristics. Conclusion The results showed that magnetic sustained release granules loaded matrine have a good sustained release effect and paramagnet- ism and the preparation process is rational and practicable. This product could be used as a new thera- peutic dosage form for digestive system tumor.

关 键 词：苦参碱 磁性缓释颗粒 壳聚糖 Fe3O4纳米粒 释放度 

分 类 号：R944.9[医药卫生—药剂学]