安络化纤丸对大鼠高脂性脂肪肝的治疗作用  

Effect of Anluohuaxianwan on hyperlipidemic fatty liver in rats

作　　者：靖旭[1] 娄海燕[1] 冯一民[1] 于晓彦[1] 王菊英[1] 张岫美[1] 

机构地区：[1]山东大学医学院药理学研究所,山东济南250012

出　　处：《中国生化药物杂志》2012年第6期717-720,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：山东省科技攻关计划(2008GG2NS02014)

摘　　要：目的探讨安络化纤丸对大鼠高脂性脂肪肝的治疗作用。方法以连续饲以高脂饲料(基础饲料加10%猪油、2%胆固醇、0.5%胆酸钠、5%蛋黄)1个月的方法建立高脂性大鼠脂肪肝模型,造模成功后给予安络化纤丸治疗4周,观察一般情况及测定血清丙氨酸氨基转换酶(ALT)、天门冬氨酸氨基转换酶(AST)、总胆固醇(TC)和甘油三酯(TG)水平,测定肝匀浆TG、丙二醛(MDA)及肝组织超氧化物歧化酶(SOD)水平,并对大鼠肝脏行病理学检查。结果安络化纤丸可明显降低高脂性脂肪肝大鼠血清ALT、AST、TC和TG水平,降低肝组织TG含量,提高肝组织SOD活性,并降低肝组织MDA水平。安络化纤丸可显著改善高脂性脂肪肝大鼠肝组织的病理损害。结论安络化纤丸对大鼠高脂性脂肪肝有明显的治疗作用,其作用可能与其抗氧化作用有关。Purpose To observe the effects of Anluohuaxianwan oo high fat diet-induced fatty liver in rats. Methods Rat fatty liver model was made by continuous feeding with high cholesterol forage for 4 weeks and then the animals were received different doses of Anluohuaxianwan for 4 weeks. General condi- tions, lanine aminotransferase （ALT） and superoxide dismutase （AST） activity, total cholesterol（ TC ） and triglyceride（TG） levels in serum were determined. TG and malondialdehyde （MDA） levels and superox- ide dismutase（SOD） activity in liver homogenate and pathological changes in liver were also tested. Re- sults Anluohuaxianwan treatment can significantly decrease serum ALT, AST and TC level, decrease the hepatic TG content, increase the hepatic SOD activity, and decrease the hepatic MDA level. The pathologi- cal observation results show that Anluohuaxianwan can significantly improve the pathological liver tissue damage of the alcoholic fatty liver. Conclusion Anluohuaxianwan has therapeutic effect on high fatty liver in rats.

关 键 词：安络化纤丸 高脂性脂肪肝 大鼠 

分 类 号：R285.5[医药卫生—中药学]