壳聚糖的物理性质对细胞活性和细胞力学性能的影响  

The Effect of Physical Properties of Chitosan on Cell Activity and on Its Mechanics Property

作　　者：田胜利[1] 田胜利(综述)[1] 叶志义(审校) 

机构地区：[1]重庆大学生物工程学院,重庆400044

出　　处：《生物医学工程学杂志》2012年第6期1212-1216,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(11172341,30570453);重庆市自然科学基金资助项目(CSTC,2010BB5082);教育部留学回国人员科研启动基金资助项目(教外司留[2011]1139号)

摘　　要：壳聚糖是通过β-(1,4)糖苷键将D-葡萄糖胺连接而成的一种天然生物聚糖,因它具有良好的生物性能,其在细胞生物学领域的应用越来越受到人们的关注。壳聚糖的物理性质和化学组成决定了以壳聚糖为基质的生物材料的性能。本文对近年来国内外有关壳聚糖物理性质对细胞活性和细胞力学性能影响的研究及进展进行了综述。结果发现:国内外相关的研究主要集中在壳聚糖对细胞活性的影响方面,而有关壳聚糖对细胞力学性能影响的研究却不多。了解相关壳聚糖对细胞的影响,有助于解释壳聚糖和细胞之间相互作用的机制,并为以后进一步的研究提供理论上的支持。Chitosan is a natural biopolymer and is made up of Dglucosamine subunits linked by β（1,4） glycosidic bond. In recent years, the application of ehitosan has attracted more and more attention because of its good biological function in cell biology. The properties of ehitosanbased biomaterial are attributed to the physical properties and chemical composition of chitosan. The author of this paper summarized recent related studies and progresses of the influence of physical properties of chitosan on cell activity and cell mechanics property at home and abroad. The find ings show that most studies mainly focused on the influence of chitosan and cell activity, while few were on cell me chanics property. The related studies of the influence of chitosan on cell will contribute to the explanation for the mechanism of the interaction between chitosan and cell, and provide the theoretical support for the further study.

关 键 词：壳聚糖 细胞活性 细胞力学性能 黏附力 

分 类 号：R318.0[医药卫生—生物医学工程]