少突胶质细胞和脊髓损伤  

Oligodendrocyte and Spinal Cord Injury

作　　者：许华燕[1] 王俊娟[1] 翟月[1] 黄波(综述)[2] 周雪(审校)[1] 

机构地区：[1]四川大学华西基础医学与法医学院,成都610041 [2]四川大学华西口腔医学院,成都610041

出　　处：《生物医学工程学杂志》2012年第6期1226-1229,共4页Journal of Biomedical Engineering

摘　　要：脊髓损伤(SCI)的过程中伴随着大量少突胶质细胞(OLs)的死亡,而OLs的死亡直接导致有髓神经纤维失去正常的电传导作用,引起脊髓的上下传导功能减弱甚至丧失,最终导致机体的感觉及运动功能损伤。因此本综述归纳了SCI后影响OLs死亡的各种微环境,并简述了OLs再生和髓鞘再生在SCI修复中的重要作用。最后针对影响OLs死亡和再生的各种因素,对SCI的治疗方式进行了分类总结,并对OLs在SCI治疗中的应用前景作了展望。Spinal cord injury （SCI） is frequently eompanied by necrosis and apoptosis of oligodendrocytes（OLs）, which contributes to demyelination of myelinated nerve fibers and their electrophysiological defects. This pathological demyelination often results in sensory or motor deficits. Here, we first focus on the mieroenvironment changes after SCI that cause OLs＇ death, then discuss the major mechanism of endogenous oligodendrocytogenesis and axonal remyelination, and finally summarize current therapies targeting OLs protection and replacement.

关 键 词：脊髓损伤 少突胶质细胞 髓鞘再生 治疗 

分 类 号：R651.2[医药卫生—外科学]