支架内再狭窄的生物力学研究进展  

Research progress in biomechanics of in-stent restenosis

作　　者：张站柱[1] 乔爱科[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《医用生物力学》2012年第6期698-702,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目(10972016;81171107);北京市自然科学基金资助项目(3092004)

摘　　要：支架介入已成为治疗心脑血管狭窄最有效的方式之一,但术后发生支架内再狭窄的问题却不可忽视。支架内再狭窄的发生,不仅与支架-血管间柔顺性失配以及支架对血管的机械性支撑引起的应力有关,而且与支架置入后血管内血流动力学环境变化引起的内膜增生有关。回顾了狭窄血管置入支架的生物力学研究历史和现状;特别从固体力学和血流动力学的角度,阐述了近年来学者对狭窄血管置入支架的生物力学数值模拟研究进展;并分析总结了支架内再狭窄的生物力学因素。从支架介入治疗过程来看,数值模拟技术可以为研究支架置入术和支架内再狭窄之间的关系提供很好的技术手段,对支架的设计以及介入治疗提供更加科学的指导。Stent intervention has become one of the most effective ways in treating cardiac and cerebral vascular stenosis. However, postoperative in-stent restenosis remains a major unsettled issue. The occurrence of in-stent restenosis is related not only to the mismatch between stent and artery, as well as the stress induced by mechan- ical support of the stent struts on arterial wall, but also to the intimal hyperplasia induced by the hemodynamic change. Recent literatures on biomechanics of the stented artery were reviewed in this paper. In particular, from the view of solid mechanics and hemodynamics, the research progress of stented artery in biomechanical simula- tion was given detailed discussion; moreover, the biomechanical factors associated with in-stent restenosis were analyzed and summarized. Numerical simulation is a good method for investigating the relationship between stent intervention and in-stent restenosis, and it also provides a scientific guideline for the design of stent structure and clinical procedure of stent intervention.

关 键 词：动脉狭窄 血流动力学 固体力学 支架介入 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程]