清开灵对脑组织谷氨酸含量及NMDA受体的影响  

Effect of QingKaiLing on glutamate and NMDA receptor of brain tissue

作　　者：岳少杰 陈检芳 陶永光 郑颂阳 杨于嘉 程冠生 罗自强 

出　　处：《湖南医科大学学报》2000年第3期213-215,共3页Bulletin of Hunan Medical University

基　　金：国家自然科学基金资助!(39700193)

摘　　要：观察清开灵对脑组织中谷氨酸 (Glu)和γ 氨基丁酸 (GABA)含量及NMDA受体的数目、亲和力的影响。结果发现 ,清开灵对脑组织中Glu ,GABA含量及Glu GABA值无明显影响 (P >0 .0 5 ) ;能明显下调神经细胞膜上NMDA受体的数目 (P <0 .0 5 )。The effects of QingKaiLing on the content of glutamate(Glu) and γaminobutyric acid(GABA), and the numbers and affinity of NmethylDaspartate(NMDA) receptor in brain tissue were observed. QingKaiLing did not change the content of Glu and GABA and the ratio of Glu/GABA in brain tissue(P>0.05). The numbers of NMDA receptor on membrane of neuron were significantly decreased in QingKaiLing group(P<0.05). These results suggested that the brain protective mechanism of QingKaiLing be in relation to decreasing the numbers of NMDA receptor. [

关 键 词：清开灵 谷氨酸 NMDA受体 大鼠 脑保护 中药 

分 类 号：R285[医药卫生—中药学]