硝酸酯与限制左室重构策略  

Nitrates and Tactics of Limiting Left Ventricular Remodeling

作　　者：童晓明[1] 张海波[1] 王志刚[1] 

机构地区：[1]山东淄博市中心医院,山东淄博255036

出　　处：《现代诊断与治疗》2000年第4期215-218,共4页Modern Diagnosis and Treatment

摘　　要：左室重构是急性心肌梗死后心脏肥大、心力衰竭和死亡的主要机制 ,而实验及临床研究表明硝酸酯能有效地限制左室重构 ,具有限制梗死面积大小、透壁心肌梗死、改善左室血流动力学和侧枝循环血流、减少再灌注损伤和抗血栓的作用 ;另外硝酸酯还具有非血流动力学、抗生长和细胞活性等优点 。Left ventricular remodeling(LVR) is the major mechanism leading to cardiac enlargement,heart failure and death after acute myocardial infarction.Experimental and clinical study indicated that nitrates can effectively limit LVR.Other benefits are mediated by limitation of infarct size and transmurality,improvement of left ventricular hemodynamics and collateral circulation,decreased reperfusion injury and antithrombotic effects.In addition to these benefits,nitrates have nonhemodynamics,antigrowth and cellular activity that limit progressive LVR.

关 键 词：心肌梗塞 左室重构 硝酸酯 药物疗法 血流动力学 

分 类 号：R542.220.6[医药卫生—心血管疾病] R541.905[医药卫生—内科学]