反复自然流产患者TORCH感染与细胞因子水平的变化  

CORRELATION OF SERUM CYTOKINE AND TORCH INFECTION WITH RECURRENT SPONTANEOUS ABORTION

作　　者：于爱莲[1] 张丰雪[1] 黄庆玉[2] 李新华[1] 陈秀春[1] 

机构地区：[1]泰山医学院病原学教研室,泰安271000 [2]泰山医学院病理学教研室

出　　处：《中国人兽共患病杂志》2000年第4期44-46,共3页Chinese Journal of Zoonoses

基　　金：山东省卫生厅资助课题

摘　　要：目的　研究反复流产患者弓形虫、巨细胞病毒、风疹病毒、单纯疱疹病毒 (TORCH)感染与 TNF、IL- 6含量的关系 ;探讨反复流产患者的发生机理。方法　采用酶联免疫吸附法检测 5 6例流产患者、2 0例早孕妇女及 2 0例非孕妇女血清中TORCH- Ig M、TNF、IL- 6的水平。结果　流产组 TORCH感染率和 TNF、IL- 6的含量明显高于正常对照组 (P<0 .0 5 ) ,多种病原体感染患者 TNF、IL- 6含量升高明显 ,TNF、IL- 6水平在正常早孕妇女及非孕妇女组无显著性差异 (P<0 .0 5 )。结论　反复流产与 TORCH感染有关 ,两种或两种以上病原体感染可能存在着病毒间的相互作用 ,加重流产的发生 ;TNF、IL -Aim In order to know the relationship in Toxoplasma gondii, Rubella virus, Cytomegalo virus, Herpes simplex virus(TORCH) infection with cytokine level and immunologic mechaism in recurrent spontaneous abortion woman. Methods TORCH IgM,TNF,IL 6 in 56 cases of recurrent spontaneous abortion, 20 cases of early pregnant and 20 cases of nonpregnant women were determind by ELISA. Results The infection rates TORCH and TNF,IL 6 levels of the abortion group were significantly elevated compared with the corresponding levels of controls(P<0.05).Level of TNF,IL 6 were higher in various kind of pathogen infection. But level of TNF,IL 6 were no difference between normal early pregnant and nonpregnant women (P>0.05).Conclusions In view of the proven fingdings that TORCH infection were important pathogens leading to recurrent spontaneous abortion. possibly, there is relationship between them in two or over two kinds of pathogen infection. TNF,IL 6 do have detrimental effects on proliferation, embry development and fetal survival.

关 键 词：反复自然流产 细胞因子 病原体 TORCH 

分 类 号：R714.210.2[医药卫生—妇产科学]