人羧酸酯酶1结构和功能的研究进展  

Progress in the structure and function of human carboxylesterase 1

作　　者：童金英[1] 易银沙[1] 曹蓬荣 刘彩云 王雷[1] 吕媛[1] 

机构地区：[1]湖南师范大学医学院,湖南长沙410006 [2]长沙赢润生物技术有限公司,湖南长沙410013

出　　处：《生物工程学报》2012年第12期1414-1422,共9页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.31170092);湖南省科技计划重点项目(No.2011SK2014);长沙市科技计划项目(No.K1104065-31)资助~~

摘　　要：人羧酸酯酶1(Human carboxylesterase 1,HCE1)是丝氨酸水解酶多基因家族的重要成员之一,它是一种参与肝脏外源物质解毒及代谢的肝羧酸酯酶。HCE1还能参与人体内胆固醇酯和游离脂肪酸的运输和代谢过程,与肝细胞肝癌的发生发展密切相关。文中就近十年来人羧酸酯酶1的分子结构、药物代谢、毒物代谢、脂质代谢及早期诊断肝细胞肝癌等功能方面的相关研究进展进行综述。Human carboxylesterase 1 （HCE1）, belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.

关 键 词：人羧酸酯酶1 药物代谢 毒物代谢 脂质代谢 诊断标志物 

分 类 号：Q55[生物学—生物化学]