急性梗阻性化脓性胆管炎细菌及抗生素敏感性分析  

The analysis of bacteria strains and sensitivity of bacteris to antibiotics in acute obstructivecholangitis with suppuration

作　　者：顾彬[1] 臧金峰 

机构地区：[1]泰州市人民医院急诊医学科,江苏省泰州225300 [2]肝胆外科

出　　处：《中华急诊医学杂志》2012年第12期1371-1373,共3页Chinese Journal of Emergency Medicine

基　　金：江苏省科技支撑计划--社会发展（BE2009611）

摘　　要：目的分析急性梗阻性化脓性胆管炎近十年前后细菌变化及其对抗生素敏感性的临床意义。方法回顾性分析泰州市人民医院1999-2001年及2009-2011年进行细菌培养的AOSC患者细菌药敏结果。结果各组细菌感染比例变化均无明显变化，铜绿假单胞菌、金黄色葡萄球菌呈上升趋势，大肠埃希菌有下降趋势；近年大肠埃希菌对环丙沙星、头孢他啶、头孢克洛及头孢曲松的敏感性差别有统计学意义；铜绿假单胞菌对头孢他啶、头孢克洛敏感性差别有统计学意义；菌药物敏感性大部分有下降趋势。结论近十年急性梗阻性化脓性胆管炎致病菌构成未见明显变化，但对药物敏感性有所下降。Objective To analyze the changes of bacteria stains in acute obstructive cholangitis with suppuration （AOSC） and sensitivity of different bactera strains to antibiotics in recent decade. Methods The data of bacterial susceptibility of AOSC patients and sensitivity of different bacteria strains to antibiotics in our hospital collected from 1999 to 2001 （group A, n =54） and from 2009 to 2011 （group B, n =62） were analyzed. Resules In group A, there were 29 male and 24 female with age range of 35 - 82 and mean age of 57.5 years, and in group B, there were 23 male and 39 female with age range of 39 - 87 and mean age of 68. 2 years. There were no differences in bacteria strains infected between two groups. However, there was a trend of increase in the proportion of the Pseudomonas aeruginosa and Staphylococcus aureus infection, and a trend of decrease in the proportion of Escherichia coli infection. The degrees of sensitivity of Escherichia coli to ciprofloxacin, ceftazidime, cefaclor and ceftriaxone were statistically different from those observed ten years ago ; and the degrees of sensitivity of Pseudomonas aeruginosa to ceftazidime and cefaclor were statistically different from those detected ten years ago as well. In recent years, the sensitivity of bacteria to antibiotics was on a downwards trend. Conclusions The pathogens of acute obstructive and suppurative eholangitis did not obviously change in recernt decade, but the sensitivity of bacteria to antibiotics was lowered.

关 键 词：急性梗阻性化脓性胆管炎 细菌培养 抗生素 药敏 

分 类 号：R446.5[医药卫生—诊断学]